Role of hypoxia and hypoxia inducible factor in physiological and pathological conditions

Mozhgan  Jahani; Kamran  Mansouri

Journal of Kermanshah University of Medical Sciences

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Role of hypoxia and hypoxia inducible factor in physiological and pathological conditions

Author(s):

Mozhgan Jahani¹,

Kamran Mansouri^1,*

1Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran

Journal of Kermanshah University of Medical Sciences:Vol. 21, issue 3; e69281

Published online:Dec 30, 2017

Article type:Review Article

Received:Jul 10, 2017

Accepted:Nov 14, 2017

How to Cite:Mozhgan JahaniKamran MansouriRole of hypoxia and hypoxia inducible factor in physiological and pathological conditions.J Kermanshah Univ Med Sci.21(3):e69281.

Abstract

Introduction: Organisms are exposed to oxygen deprivation (Hypoxia) in various physiological and pathological conditions. There are different conserve evolutionary responses to counterview with this stress that primary transcriptional response to stress related to hypoxia is interceded by hypoxia-inducible factor (HIF-1) in mammals. This factor can regulate different genes that have essential roles in adaptation to this condition. In this review, the role of this factor in physiological and pathological conditions under hypoxic condition has been evaluated after examining structural features and regulation characteristics of HIF-1.

Methods: First, articles related to the keywords of hypoxia and HIF-1 (from 1991-2016) were searched from valid databases such as Springer Link, Google Scholar, PubMed and Science direct. Then, the articles correlated with hypoxia, HIF-1 and their roles in physiological and pathological conditions (120 articles) were searched and just 64 articles were selected for this study.

Result: According to studies, there are different genes in cells and organs that can be regulated by HIF-1. Activation of genes expression by this protein occurs through its linkage to cis-acting of 50 base pair hypoxia response element (HRE) region located in their promotor and enhancer. Depending on circumstances, activation of these genes can be beneficial or harmful.

Conclusion: Activation of different genes in hypoxia by HIF-1 has different effects on physiological and pathological conditions. Therefore, HIF-1, as a hypoxia-inducible factor in hypoxic conditions, plays an essential role in the adaptation of cells and organs to changes related to the presence of oxygen.

Keywords

Hypoxia

HIF-1

cancer

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