The effect of 6-week high intensity interval training on the VEGF/COL-18 ratio and some echocardiographic indices in rats with myocardial infarction

authors:

avatar Abbas Ali Gaeini 1 , avatar Mohammad Reza Kordi 1 , avatar Reza Nuri 2 , avatar Pedram Ghorbani 2 , avatar Sara Karbalaeifar 2 , *

Dept. of Physical education, University of Tehran, Tehran, Iran
Dept. of Physical education, University of Tehran, Kish international campus, Kish, Iran
Journal of Kermanshah University of Medical Sciences: Vol.20, issue 3; e69691
published online: December 19, 2016
article type: Original Article
received: May 30, 2016
accepted: November 10, 2016
DOI: https://doi.org/10.22110/jkums.v20i3.3292

how to cite: Gaeini A A, Kordi M R, Nuri R, Ghorbani P, Karbalaeifar S. The effect of 6-week high intensity interval training on the VEGF/COL-18 ratio and some echocardiographic indices in rats with myocardial infarction. J Kermanshah Univ Med Sci. 2016;20(3):e69691. https://doi.org/10.22110/jkums.v20i3.3292.

Abstract

Introduction: Myocardial infarction (MI) is the irreversible cell death caused by ischemia in parts of myocardium. The molecular process of increased capillary density in response to activity and its appropriate intensity is not clear yet. Therefore, this research aimed to evaluate the effect of 6-week high intensity interval training on the VEGF/COL-18 ratio and echocardiographic indices in rats with MI.
Methods: Twelve Wistar male rats of 10 weeks old and mean weight 250-300gr were allocated to two groups of experimental (60 minutes of interval treadmill running for four minutes with the intensity of 85-90 and two minutes of active rest at 50-60 percent of VO2max for four days a week for 6 weeks) and control group (without any training). Real-time PCR was used to assess the expression of VEGF and COL-18 genes after inducing MI, and shortening fractional and ejection fraction were investigated as echocardiographic indices. Data were analyzed in SPSS18 using independent t test (α≤ 0.05).
Results: The findings showed that there was no significant increase in the VEGF/COL-18 ratio in the HIIT group (1.856 mg/ml) as compared with the control group (1.245 mg/ml) (p=0.263). A significant increase was observed in the HIIT group for SF (77.461±7.022%) and EF (41.625±6.847%) as compared with the control group (64.483±3.695%) and (31.320±3.460%), respectively (p=0.001).
Conclusion: In general, 6 weeks of high intensity interval training can effectively increase angiogenesis factors and improve myocardial function in male Wistar rats after MI.

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