Abstract
Introduction: Controlling and reducing serum uric acid levels may have beneficial effects on blood pressure control. The current study was carried out to assess the effects of allopurinol administration on serum uric acid and arterial blood pressure among the patients under hemodialysis.
Methods: This double-blind clinical trial was conducted on 132 hemodialysis patients (two separate groups) suffering from hyperuricemia and hypertension at Imam Reza hospital, Kermanshah in 2014. The first group received a daily dose of 100 mg allopurinol and the second group, as control, received placebo. The demographic data, vital signs, paraclinical data and comorbidities of all patients were recorded in a checklist. Serum uric acid and blood pressure were measured at the end of the first, second and third months. The obtained data were analyzed by SPSS software using t-test, paired t-test and repeated measure t-test.
Results: The results showed that allopurinol significantly reduced systolic and diastolic blood pressure and uric acid level in the patients with chronic renal dysfunction. This reduction was also reported to be significant between the patient and control groups at different times.
Conclusion: Given the beneficial effect of allopurinol on the patients with chronic renal dysfunction, this drug can be used in this group of patients.
Keywords
Allopurinol serum uric acid arterial blood pressure hemodialysis
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© 2016, Journal of Kermanshah University of Medical Sciences. This open-access article is available under the Creative Commons Attribution-NonCommercial 4.0 (CC BY-NC 4.0) International License (https://creativecommons.org/licenses/by-nc/4.0/), which allows for the copying and redistribution of the material only for noncommercial purposes, provided that the original work is properly cited.