Background: Crocin is one of the main components of saffron. The effect of saffron on birth abortion has been established. So, the possible effect of crocin on abortion was evaluated in this study.
Methods: Pregnant mice were divided into 8 groups. Each group received crocin (0 or 10 or 50 or 100 mg/kg, i.p.) from the first to the fifth day of pregnancy. Then, the first four groups were sacrificed on the seventh day to evaluate the implantation sites. The other four groups were sacrificed on the 20th day and the number of embryos was counted. Data were analyzed by ANOVA.
Results: Administration of crocin (50 and 100 mg/kg) significantly reduced the mean number of implantation sites and embryos compared to the control group (P<0.05).
Conclusion: Administration of high doses of crocin in the first week of pregnancy reduced the number of implantation places and embryos in mice.
© 2015, Journal of Kermanshah University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.