Immunity to rubella disease among people under 25 years in Ahvaz in 2013

authors:

avatar Abdolhussein Shakurnia 1 , avatar Mehri Ghafourian Boroujerdnia 1 , * , avatar Seyed Mohammad Alavi 2 , avatar Reza Nurouzi Rad 3 , avatar Ghodratollah Shakerinejad 4 , avatar Amir Arsalan Serajian 4

Health Research Institute, Infectious and Tropical Diseases Research Center, Dept. of Immunology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Health Research Institute, Infectious and Tropical Diseases Research Center, Dept. of Infectious disease, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Dept. of Biochemistry , Faculty of Medicine, Dezful University of Medical Sciences, Dezful, Iran
Health education research center, Gahad-e-daneshgahi Khouzestan, Ahvaz, Iran
Journal of Kermanshah University of Medical Sciences: Vol.18, issue 5; e74098
published online: August 29, 2014
article type: Research Article
received: March 14, 2014
accepted: August 05, 2014
DOI: https://doi.org/10.22110/jkums.v18i5.1539

how to cite: Shakurnia A, Ghafourian Boroujerdnia M, Alavi S M, Nurouzi Rad R, Shakerinejad G, et al. Immunity to rubella disease among people under 25 years in Ahvaz in 2013. J Kermanshah Univ Med Sci. 2014;18(5):e74098. https://doi.org/10.22110/jkums.v18i5.1539.

Abstract

Background: Rubella is an important childhood infectious disease caused by rubella virus. Complications of rubella, except in pregnant women, are negligible, but its importance is due to congenital rubella syndrome. To control the effects of congenital complications, rubella vaccination program is run. The goal of this study was to evaluate the status of immunity to rubella in Ahvaz, Iran.
 Methods: In this cross - sectional study, anti-rubella IgG antibodies were investigated in 865 individuals aged 1-25 years by ELISA method. The cut-off values of more than 11 IU / ml was considered as immune. Data were analyzed by SPSS-18 software using chi-square, ANOVA and Pearson correlation.
Results: Of the study subjects, 563 patients were female (65%) and 302 patients were male (35%) with the mean age of 12.7±7.1 yr. Seven hundred fifty nine subjects (87.7%) were immune against rubella. The level of immunity to rubella was different in various age groups (p=0.0001). The highest level of immunity (97.2%) was observed in the 19-25 year-old patients and the lowest level (79.0%) was seen in the 1-6 year-old individuals. Immunity rates were significantly higher in females than in males (P=0.010). Pearson correlation showed a significantly positive relationship between age and antibody titer. The antibody titer also increased with age increase (r=0.365; P=0.001).
Conclusion: The results of this study show that rubella vaccination program has been successful to create an appropriate immunity against rubella, especially in 19-25 year-old females, the main high-risk group.

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