Prevalence of hepatitis C genotypes in patients with hepatitis C in Lorestan province (2009-2013)

Mohammad Reza Nazer; Behrouz Beiranvand; Zia Obeidavi; Omid Beiki

doi:10.22110/jkums.v18i2.1358

Journal of Kermanshah University of Medical Sciences

Peer-reviewed Medical Quarterly

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https://doi.org/10.22110/jkums.v18i2.1358

Prevalence of hepatitis C genotypes in patients with hepatitis C in Lorestan province (2009-2013)

Author(s):

Mohammad Reza Nazer¹,

Behrouz Beiranvand^2,*,

Zia Obeidavi³,

Omid Beiki⁴

1Dept. of Infectious Diseases, Hepatitis Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran

2Dept. of Biostatics, Kermanshah University of Medical Sciences, Kermanshah, Iran

3Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran

4Research Center for Environmental Determinants of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran

Journal of Kermanshah University of Medical Sciences:Vol. 18, issue 2; e74169

Published online:May 29, 2014

Article type:Research Article

Received:Dec 01, 2013

Accepted:Apr 29, 2014

How to Cite:Mohammad Reza NazerBehrouz BeiranvandZia ObeidaviOmid BeikiPrevalence of hepatitis C genotypes in patients with hepatitis C in Lorestan province (2009-2013).J Kermanshah Univ Med Sci.18(2):e74169.https://doi.org/10.22110/jkums.v18i2.1358.

Abstract

Background: Determining hepatitis C genotypes is important to detect the various aspects of this infection, including its epidemiology, pathogenesis and response to anti-viral treatments. The aim of this study was to investigate the prevalence of hepatitis C genotypes in patients admitted to the Infectious Diseases Clinic in Khorramabad.

Methods: Out of all the patients admitted to the Infectious Disease Clinic in Khorramabad in a four-year period (April 2009 to March 2013), 120 patients who met the inclusion criteria of the study were evaluated. The PCR method was used to examine the serums of the patients with hepatitis C in terms of the type of genotype.

Results: Out of 120 patients, 101 (84.2%) were male and 19 (15.8%) were female. The most prevalent genotypes were 3a (65%), 1a (24.2%), 1a/1b (5%), and 2 (1.7%), respectively. The genotypes of 5 patients (4.2%) could not be determined. No significant relationships were found between gender and genotype, and age group and genotype. Moreover, 18.3% of the patients were HIV-positive.

Conclusion: In this study, genotype 3a, the most prevalent genotype, was not consistent with the prevalent genotypes in Arab, European, American, and African countries. Furthermore, genotype 1a was the second most prevalent genotype, while it has been reported as the most prevalent genotype by numerous studies conducted in Iran.

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Author(s):

Mohammad Reza Nazer:[PubMed][Scholar]
Behrouz Beiranvand:[PubMed][Scholar]
Zia Obeidavi:[PubMed][Scholar]
Omid Beiki:[PubMed][Scholar]