Association between CTLA-4 polymorphism and systemic lupus erythematosus

authors:

avatar Mahdieh Shojaa 1 , avatar Patricia Khashayar 2 , avatar Mahsa Amoli 3 , avatar Mehrdad Aghaie 4 , * , avatar Mostafa Qorbani 5 , avatar Mahmoud Akbarian 6 , avatar Neda Ranjbar Pour 7 , avatar Arghavan Kouroshnia 3

Deputy of Research and Technology, Golestan University of Medical Sciences, Gorgan, Iran
Osteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
Endocrinology & Metabolism Research Center (EMRC), Tehran University of Medical Sciences, Tehran, Iran
Dept. of Rheumatology, Faculty of Medicine, Bone Joint and Connective Tissue Research Center (BJCRC), Golestan University of Medical Sciences, Gorgan, Iran
Dept. of Public Health, Alborz University of Medical Sciencesand Non-communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
Rheumatology Research Center, Tehran University of Medical Sciences,Tehran, Iran
Genetic Department, Islamic Azad University, Tehran branch, Tehran, Iran

how to cite: Shojaa M, Khashayar P, Amoli M, Aghaie M, Qorbani M, et al. Association between CTLA-4 polymorphism and systemic lupus erythematosus. J Kermanshah Univ Med Sci. 2014;17(10):e74330. doi: 10.22110/jkums.v17i10.1167.

Abstract

Background: Cytotoxic lymphocyte antigen-4 (CTLA-4) plays an important role in regulating T cell activities. CTLA-4 gene polymorphisms are associated with genetic susceptibility to various autoimmune diseases, including systemic lupus erythematosus (SLE). The present study was conducted to analyze the role of CTLA-4 polymorphism at positions −1722TC in patients suffering from SLE.
Methods: Samples were collected from 180 SLE patients and 304 healthy people. Both groups were equal in terms of age and ethnicity. Polymerase chain reaction restriction fragments length polymorphism (PCR-RFLP) was used to analyze the genotype and allele frequencies of these polymorphisms. Data were analyzed by SPSS software.
Results: No statistically significant difference was observed between the studied genotypic and allelic frequencies, SLE patients and the controls. There was a significant correlation between age range 15-45 and TT genotype (P<0.0001). However,  no significant correlation was found between other risk factors and different genotypes.
Conclusion: The results suggested that 1722TC polymorphism in the promoter region of the CTLA-4 gene does not play any role in the genetic susceptibility to SLE.

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