Evaluation of the relationship between WBC, HS.CRP and secondary pulmonary hypertension in patients with COPD

Khalil Ansarin; Farid Rashidi; Mohammad Reza Ghaffari; Hossein Namdar; Akbar Sharifi

doi:10.22110/jkums.v17i10.1213

Journal of Kermanshah University of Medical Sciences

Peer-reviewed Medical Quarterly

Home

Current Issue All Issues In Press Accepted Manuscripts Search

Instructions

Journal Information Boards and Committees Indexing and Listing Sources Journal Metrics Open Peer Review (OPR)Publication Ethics and Malpractice Statement Reviewer and AE Registration Form Contact Us Support

Authors Guide Submit Manuscript

https://doi.org/10.22110/jkums.v17i10.1213

Evaluation of the relationship between WBC, HS.CRP and secondary pulmonary hypertension in patients with COPD

Author(s):

Khalil Ansarin¹,

Farid Rashidi^2,*,

Mohammad Reza Ghaffari¹,

Hossein Namdar³,

Akbar Sharifi¹

1Dept. of Internal Medicine, Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

2Dept. of Internal Medicine, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran

3Dept. of Cardiology, Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

Journal of Kermanshah University of Medical Sciences:Vol. 17, issue 10; e74331

Published online:Jan 29, 2014

Article type:Research Article

Received:Jun 10, 2013

Accepted:Oct 29, 2013

How to Cite:Khalil AnsarinFarid RashidiMohammad Reza GhaffariHossein NamdarAkbar SharifiEvaluation of the relationship between WBC, HS.CRP and secondary pulmonary hypertension in patients with COPD.J Kermanshah Univ Med Sci.17(10):e74331.https://doi.org/10.22110/jkums.v17i10.1213.

Abstract

Background: Inflammatory mechanisms appear to play a major role in pathogenesis of various types of pulmonary hypertension such as idiopatic PAH (iPAH). Although inflammatory factors such as IL6 and TNFa play an important role in IPAH, there is limited information about the relationship between acute phase reactants and pulmonary hypertension occurring secondary to pulmonary diseases such as chronic obstructive pulmonary diseases (COPD).

Methods: This cross-sectional study was carried out on 94 patients with COPD. Patients with a recent history of systemic corticosteroid use, infection, trauma or surgery, and gastrointestinal bleeding were excluded. Body plethysmography and transthoracic echocardiography were performed. Blood samples were taken from all patients and sent for complete blood count (CBC) and hsCRP tests.

Results: Twenty patients (28.6%) had pulmonary hypertension. There was a significant difference between the mean of WBC in patients with and without pulmonary hypertension (8505 mic/lit vs. 7044 mic/lit) (p=0.04). There was also a significant difference between the hs.CRP in patients with and without pulmonary hypertension (8.8pg/ml vs. 4.07pg/ml) (p=0.032). After adjustment of age, sex, serum hemoglobin, hematocrit, O2sat, FEV1 and FVC, the relationship between the IL6, white blood cell count, HS.CRP and pulmonary hypertension remained significant (p=0.018, p=0.022).

Conclusion: Inflammatory factors such as white blood cell and HS.CRP are independent risk factors of pulmonary hypertension in COPD patients.

Keywords

COPD

pulmonary hypertension

HS.CRP

WBC

Fulltext

References

1.
The references of this article is available on PDF.

comments

Crossmark

Checking

Share on

Comments

Number of Comments:0

Cited by

CrossRef 0

Metrics

Get Permission (article level)

Purchasing Reprints

Copyright Clearance Center (CCC) handles bulk orders for article reprints for Brieflands. To place an order for reprints, please click here ( https://www.copyright.com/landing/reprintsinquiryform/ ). Clicking this link will bring you to a CCC request form where you can provide the details of your order. Once complete, please click the ‘Submit Request’ button and CCC’s Reprints Services team will generate a quote for your review.

Search Relations

Author(s):

Khalil Ansarin:[PubMed][Scholar]
Farid Rashidi:[PubMed][Scholar]
Mohammad Reza Ghaffari:[PubMed][Scholar]
Hossein Namdar:[PubMed][Scholar]
Akbar Sharifi:[PubMed][Scholar]