Journal of Kermanshah University of Medical Sciences
Peer-reviewed Medical Quarterly
e-ISSN 2588-2570
p-ISSN 2588-2562
Outline
The association between glutathione s-transfrases T1, M1, and P1 polymorphisms with end stage renal disease
Authors
1Dept. of Biochemistry, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
2Kidney Transplantation Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
*Corresponding Author: Corresponding author: Ali Aidy, Dept. of Biochemistry, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran, Tel: +98 9187697906 Email: [email protected]
Published online:Nov 29, 2013
Article type:Research Article
Received:Apr 13, 2013
Accepted:Sep 10, 2013
How to Cite:Nomani H, Aidy A, Vaisi Raygani A, HaghNazari L, Reissi D, et al. The association between glutathione s-transfrases T1, M1, and P1 polymorphisms with end stage renal disease. J Kermanshah Univ Med Sci. 2013;17(8):e74390. doi:
Abstract
Background: End stage renal disease or ESRD is a progressive and irreversible deterioration in renal function in which the body loses ability to maintain metabolical balance, fluid and electrolytes. Glutathione s-transfrases (GSTs) are members of multigenic family which have essential role as an antioxidant in the cells. In this study, the polymorphism of GST, T1, M1 & P in ESRD patients were compared with those of control groups to determine the possible relationship between polymorphism of these enzymes and ESRD.
Methods: 136 of ESRD patients as experimental and 137 of healthy individuals as control group were examined. The GST T1 & M1 genotypes were determined in all individuals with multiplex- PCR and GST P1 polymorphism was determined with PCR-RFLP.
Results: The distribution of GSTT1& M1 of T1⁺-M1⁺(wild), T1⁺-M1¯, T1¯-M1⁺and T1¯-M1¯(null) genotypes in control group were 45(32.8%), 40(29.2%), 28(20.4%) and 24(17.5%) and in experimental group were17(12.8%), 46(34.6%), 21(15.8%) and 49(36.8%) respectively (P<0.001).
Conclusion: As the reduction of GST T1⁺-M1⁺ (wild) was observed with more frequency in patients with ESRD compared to control group (12.8%vs.32.8%), this genotype can be associated with the risk of ESRD.
References
- 1.The references of this article is available on PDF.
Copyright
© 2013, Journal of Kermanshah University of Medical Sciences. This open-access article is available under the Creative Commons Attribution-NonCommercial 4.0 (CC BY-NC 4.0) International License (https://creativecommons.org/licenses/by-nc/4.0/), which allows for the copying and redistribution of the material only for noncommercial purposes, provided that the original work is properly cited.
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