The comparison between metronidazole and the combination of metronidazole and probiotic on the treatment of bacterial vaginosis (BV)

Hoda Tafazzoli Harandi; Seddigheh Amir Ali Akbari; Maryam  Afrakhteh; Hamid Alavi Majd; Soheila Nouraie

Journal of Kermanshah University of Medical Sciences

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The comparison between metronidazole and the combination of metronidazole and probiotic on the treatment of bacterial vaginosis (BV)

Author(s):

Hoda Tafazzoli Harandi¹,

Seddigheh Amir Ali Akbari^2,*,

Maryam Afrakhteh³,

Hamid Alavi Majd⁴,

Soheila Nouraie²

1Breast Cancer Research Center (BCRC), Academic Center for Education, Culture and Research (ACECR),Tehran University of Medical Sciences, Tehran, Iran

2Dept. of Midwifery, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran

3Dept. of Obstetrics & Gynecology, Shahid Beheshti University of Medical Sciences, Tehran, Iran

4Dept. of Biostatistics, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Journal of Kermanshah University of Medical Sciences:Vol. 17, issue 2; e77119

Published online:May 29, 2013

Article type:Research Article

Received:May 28, 2012

Accepted:Nov 20, 2012

How to Cite:Tafazzoli Harandi H, Amir Ali Akbari S, Afrakhteh M, Alavi Majd H, Nouraie S. The comparison between metronidazole and the combination of metronidazole and probiotic on the treatment of bacterial vaginosis (BV).J Kermanshah Univ Med Sci.2013;17(2):e77119.

Abstract

Background: Due to high occurrence of Bacterial Vaginosis among women and its resistance to drug we need a new treatment regimen for improving the efficacy of present treatments. The objective of this study was to investigate the comparison between Metronidazole and the combination of metronidazole and probiotic on the treatment of bacterial vaginosis.

Methods: This clinical-experimental study was done on eighty women referred to clinics of Shahid Beheshti University of Medical Sciences in 2011. The data gathered via using observation check list, microscope, and PH paper. Bacterial vaginosis diagnosed by Amsel criteria. The patients were divided into two groups of metronidazole and the combination of metronidazole and probiotic. Amsel criteria and patients’ complaints before treatment and 3-7 days after treatment were recorded. Data were analyzed employing inferential statistics by SPSS 17.

Results: Metronidazole and the combination of metronidazole and probiotic had an equal effect on the decreasing vaginal discharge, mal odour, vaginal pruritis and dysuria. All Amsel criteria have an equal effect in both groups before and after treatment too, but the difference between both groups was statistically significant with regard to treatment response and the combination of metronidazole and probiotic had a better efficiency (P<0.05). According to the study significant reduction in Amsel criteria and complaints was observed in both groups (P<0.001).

Conclusion: The study shows that supplementary treatment combining probiotic improve the efficacy BV therapy (P<0.05).

Keywords

bacterial vaginosis

metronidazole

probiotic

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