Comparing dexamethasone and metoclopramide for preventing nausea and vomiting and pain after hernia inguinal surgery

Rasool Kavyannejad; MahmoodReza Kohan; Zamane Hosaini; Glaviz Zandkarimi

Journal of Kermanshah University of Medical Sciences

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Comparing dexamethasone and metoclopramide for preventing nausea and vomiting and pain after hernia inguinal surgery

Author(s):

Rasool Kavyannejad^1,*,

MahmoodReza Kohan²,

Zamane Hosaini³,

Glaviz Zandkarimi³

1Intensive Care Unit (ICU), Imam Reza Hospital, Kermanshah University of Medical Science, Kermanshah, Iran

2Dept. of Anesthesiology, School of Medicine, Kurdestan University of Medical Sciences, Sanandaj, Iran

3School of Nursing, Kurdestan University of Medical Sciences, Sanandaj, Iran

Journal of Kermanshah University of Medical Sciences:Vol. 17, issue 1; e77137

Published online:Apr 29, 2013

Article type:Research Article

Received:May 01, 2012

Accepted:Sep 25, 2012

How to Cite:Rasool KavyannejadMahmoodReza KohanZamane HosainiGlaviz ZandkarimiComparing dexamethasone and metoclopramide for preventing nausea and vomiting and pain after hernia inguinal surgery.J Kermanshah Univ Med Sci.17(1):e77137.

Abstract

Background: Postoperative nausea and vomiting (PONV) is the commonest consequence after surgery which can lead to multiple difficulties on different body systems. The aim of this study was to compare Dexamethasone and Metoclopramide effect in preventing PONV and pain.

Methods: In a clinical trial, 60 ASA 1-2 patients who were candidate for elective inguinal surgery were randomly divided into two equal groups. One group (M) received the intravenous 10mg Metoclopramide and the other group (D) received 8mg Dexamethasone 10 min before extubation and 6 hours after the end of the surgery. The indication of PONV, the time to the first request for analgesic and the amount of analgesic in the course was recorded 24 hours after surgery. Data was analyzed using SPSS version 16.

Results: The indication of PONV had no significant difference in both groups (P>0.05). The time to the first request for analgesic in group (M) was less than group (D) (p=0.063) and the amount of used analgesic in group (D) was less than group (M) (p=0.177) but had no significant difference. Prescription frequency of analgesic was significantly lower in dexamethasone group (P=0.033).

Conclusion: There was no statistically significant difference between two groups in the rate of PONV, but due to the analgesia effects of Dexamethasone, using this drug after surgery is recommended.

Keywords

metoclopramide

dexamethasone

postoperative nausea and vomiting

pain

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