Abstract
Background: Postoperative nausea and vomiting (PONV) is the commonest consequence after surgery which can lead to multiple difficulties on different body systems. The aim of this study was to compare Dexamethasone and Metoclopramide effect in preventing PONV and pain.
Methods: In a clinical trial, 60 ASA 1-2 patients who were candidate for elective inguinal surgery were randomly divided into two equal groups. One group (M) received the intravenous 10mg Metoclopramide and the other group (D) received 8mg Dexamethasone 10 min before extubation and 6 hours after the end of the surgery. The indication of PONV, the time to the first request for analgesic and the amount of analgesic in the course was recorded 24 hours after surgery. Data was analyzed using SPSS version 16.
Results: The indication of PONV had no significant difference in both groups (P>0.05). The time to the first request for analgesic in group (M) was less than group (D) (p=0.063) and the amount of used analgesic in group (D) was less than group (M) (p=0.177) but had no significant difference. Prescription frequency of analgesic was significantly lower in dexamethasone group (P=0.033).
Conclusion: There was no statistically significant difference between two groups in the rate of PONV, but due to the analgesia effects of Dexamethasone, using this drug after surgery is recommended.
Keywords
metoclopramide dexamethasone postoperative nausea and vomiting pain
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© 2013, Journal of Kermanshah University of Medical Sciences. This open-access article is available under the Creative Commons Attribution-NonCommercial 4.0 (CC BY-NC 4.0) International License (https://creativecommons.org/licenses/by-nc/4.0/), which allows for the copying and redistribution of the material only for noncommercial purposes, provided that the original work is properly cited.