Effects of morphine dependency and its abstinence on serum concentrations of sex hormones and reproductive system in male rats

Mahnaz Ghowsi; Namdar Yousofvand; Ali Pourmotabbed

Journal of Kermanshah University of Medical Sciences

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Effects of morphine dependency and its abstinence on serum concentrations of sex hormones and reproductive system in male rats

Author(s):

Mahnaz Ghowsi¹,

Namdar Yousofvand^1,*,

Ali Pourmotabbed²

1Dept. of Biology, Faculty of Science, Razi University, Kermanshah, Iran

2Dept. of Physiology and Pharmacology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran

Journal of Kermanshah University of Medical Sciences:Vol. 17, issue 1; e77138

Published online:Apr 29, 2013

Article type:Research Article

Received:Jun 11, 2012

Accepted:Nov 27, 2012

How to Cite:Mahnaz GhowsiNamdar YousofvandAli PourmotabbedEffects of morphine dependency and its abstinence on serum concentrations of sex hormones and reproductive system in male rats.J Kermanshah Univ Med Sci.17(1):e77138.

Abstract

Background: The study was performed to investigate the effects of morphine dependency and morphine withdrawal on the reproductive system of adult male rat(Wistar).

Methods: 32 adult male rat divided into 5 groups. Animals in the control group (n=8) received normal saline (1ml/kg) twice daily subcutaneously for 30 consecutive days. Animals in dependent group (n=8) received morphine (10mg/ml/kg). In 2 other groups (n=4) withdrawal syndrome signs were evaluated with naloxone injection (4mg/kg). Receiving morphine for 30 days, animals of the withdrawal group (n=8) didn’t receive any drug for 14 consecutive days (spontaneous withdrawal).

Results: The data showed that in the morphine dependent animals serum levels of luteinizing hormone (LH) and testosterone as well as partial weights of prostates and seminal vesicles, weights of prostates and seminal vesicles, and seminal vesicles contents reduced as compared with control group (p<0.05). In the withdrawal group seminal vesicles contents were lower than the control group (p<0.05).

Conclusion: Results of this study indicate that morphine dependency influence the sex hormone concentrations in serum and reproductive system and may cause reduction in fertility and libido decline in men.

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