Effects of simultaneous Formaldehyde vapor and noise exposure on pituitary-gonadal axis in adult male mice

Shahram Vosoughi; Hassan Asilian Mahabadi; Ali Khavanin; Mojdeh Salehnia; Abdolhossein Shahverdi; Vahid Esmaeili; Ardalan Soleimanian

Journal of Kermanshah University of Medical Sciences

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Effects of simultaneous Formaldehyde vapor and noise exposure on pituitary-gonadal axis in adult male mice

Author(s):

Shahram Vosoughi¹,

Hassan Asilian Mahabadi^2,*,

Ali Khavanin²,

Mojdeh Salehnia³,

Abdolhossein Shahverdi⁴,

Vahid Esmaeili⁴,

Ardalan Soleimanian²

1Dept. of Health Sciences, School of Health, Safety and Environment, Shahid Beheshti University of Medical Sciences, Tehran, Iran

2Dept. of Occupational and Environmental Health, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran

3Dept. of Anatomical Sciences, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran

4Embryology Department, Reproductive Biomedicine Research Center, Royan Institute, ACECR, Tehran, Iran

Journal of Kermanshah University of Medical Sciences:Vol. 16, issue 8; e77270

Published online:Mar 29, 2013

Article type:Research Article

Received:Apr 10, 2012

Accepted:Jul 24, 2012

How to Cite:Shahram VosoughiHassan Asilian MahabadiAli KhavaninMojdeh SalehniaAbdolhossein ShahverdiVahid EsmaeiliArdalan Soleimanianet al.Effects of simultaneous Formaldehyde vapor and noise exposure on pituitary-gonadal axis in adult male mice.J Kermanshah Univ Med Sci.16(8):e77270.

Abstract

Background: Formaldehyde (H2C = O), is a member of aldehyde family with a simplest organic molecule, used in various industries. The aim of this experimental study was to investigate the effects of simultaneous formaldehyde and noise exposure on hormonal pituitary-gonadal axis in adult male mice.

Methods: 46 adult male mice were randomly assigned to one control group and three experimental groups which were exposed to formaldehyde vapor (10 ppm) (F), noise (100 dB) (N), and simultaneous formaldehyde with noise (NF), respectively for 10 days (8 hours a day). At the end of the experiment half of the mice of each group were sacrificed 24 hours after exposure (short-term effects) and the rest were sacrificed 35 days after the end of exposure (long-term effects). Plasma concentrations of testosterone, LH, FSH were measured using the ELISA method.

Results: In short-term analysis, the serum testosterone in groups N, F, and NF were 2.73±0.24, 2.58±0.16, and 2.03±0.22,(Ng/ml)respectively which had a significant decrease (p<0.001)compared to control group(3.82±0.35). The LH level in groups F, and NF also showed significant reduction compared to control group (p<0.05 and p<0.001).

Conclusion: Reduction of serum testosterone and LH level may be potentiated by noise (700-5700 HZ) in the simultaneous exposure to formaldehyde and noise.

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