Comparison of homocysteine levels in amniotic fluid and simultaneously blood serum between severe preeclamptic women and control group

authors:

avatar Shohreh Malek khosravi 1 , * , avatar Negin Rezavand 1 , avatar Maryam Zangeneh 1 , avatar Firoozeh Veisi 1 , avatar Neda Soleimani Abyaneh 2 , avatar Hamid Nomani 3 , avatar Mansour Rezaei 4 , avatar Mojgan Kohzadi 1

High Risk Pregnancy Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
Dept. of Biochemistry , School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
Dept. of Biostatistics, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
Journal of Kermanshah University of Medical Sciences: Vol.16, issue 7; e77289
published online: February 27, 2013
article type: Research Article
received: February 18, 2012
accepted: July 03, 2012

how to cite: Malek khosravi S, Rezavand N, Zangeneh M, Veisi F, Soleimani Abyaneh N, et al. Comparison of homocysteine levels in amniotic fluid and simultaneously blood serum between severe preeclamptic women and control group. J Kermanshah Univ Med Sci. 2013;16(7):e77289. 

Abstract

Background: previous studies have shown that preeclampsia is associated with elevated maternal serum homocysteine levels, but few studies have evaluated homocysteine levels in amniotic fluid in these patients. The purpose of this study was to compare amniotic fluid homocysteine levels in preeclamptic women, with those of normal pregnant women.
Methods: A cross sectional study was done on 46 pregnant women with severe preeclampsia and 46 normal pregnant women. Homocysteine levels in amniotic fluid and maternal serum were compared in two groups. Data were analyzed using t test and leven's test.
Results: The mean serum homocysteine levels in the third trimester of pregnancy in the preeclamptic women was 3.965 +/- 1.8 and in normal group was 3.05 +/- 1.87 which was statistically significant (P.v=0.019). The mean amniotic fluid homocysteine levels in the third trimester of pregnancy in mothers with severe preeclampsia was 11.11 +/- 7.41 and in the control group was 8.15 +/- 5.71, in which the difference was statistically significant (P.v=0.035). The average of differences between serum and amniotic fluid homocysteine levels in preeclamptic group was 7.14 +/- 6.01 and the average of differences in normal group was 5.1 +/- 4.34, there were no statistically significant differences between two groups (P.v=0.065)
Conclusion: In the patients with severe preeclampsia, homocysteine levels in serum and amniotic fluid were higher than those of normal pregnant women. Higher homocysteine levels in amniotic fluid of preeclamptic women could indicate the role of the fetus in producing of the preeclampsia.

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