The relationship of insulin resistance with adiponectin in adult males with mild to moderate asthma

Mojtaba Izadi; Farzad Nazem; Homa Masrour; Davood Khorshidi

Journal of Kermanshah University of Medical Sciences

Peer-reviewed Medical Quarterly

Current Issue All Issues In Press Accepted Manuscripts Search

Journal Information Boards and Committees Indexing and Listing Sources Journal Metrics Open Peer Review (OPR)Publication Ethics and Malpractice Statement Reviewer and AE Registration Form Contact Us Support

Authors Guide Submit Manuscript

The relationship of insulin resistance with adiponectin in adult males with mild to moderate asthma

Author(s):

Mojtaba Izadi^1,*,

Farzad Nazem²,

Homa Masrour³,

Davood Khorshidi¹

1Dept. of Athletic Sciences, Islamic Azad University, Saveh, Iran

2Dept. of Athletic Sciences, Boalisina University, Hamadan, Iran

3Dept. of Internal Medicine, Islamic Azad University, Saveh, Iran

Journal of Kermanshah University of Medical Sciences:Vol. 16, issue 3; e78802

Published online:Sep 29, 2012

Article type:Research Article

Received:Jul 23, 2011

Accepted:Dec 27, 2011

How to Cite:Mojtaba IzadiFarzad NazemHoma MasrourDavood KhorshidiThe relationship of insulin resistance with adiponectin in adult males with mild to moderate asthma.J Kermanshah Univ Med Sci.16(3):e78802.

Abstract

Background: Obesity and overweight are accompanied with insulin resistance markers and diagnosed as a metabolic risk factor in prevalence and develop the asthma severity. Regardless of biological role of inflammation markers in asthma, the effective mechanisms in relation to obesity and asthma are not fully understood.

Methods: This study investigates the relationship between insulin resistance (HOMA-IR) and adiponectin with respiratory clinical parameters in obese chronic asthma patients. Thirty nine obese adult males aged 35 – 50 years with mild to moderate asthma participated in this study voluntarily. Asthma and its severity were diagnosed by spirometry test. Blood sampling obtained for measuring baseline levels of serum adiponectin, glucose and insulin after 10-12 hours overnight fast. Insulin resistance calculated by fasting insulin and glucose. Pierson correlation used to determine the relationship between baseline adiponectin with insulin resistance and respiratory variables.

Results: A significantly positive correlation observed between serum adiponectin and FEV1/FVC (p = 0.001, R= 0.43). There was no significant relationship between plasma ghrelin and insulin resistance (p=0.446). Serum adiponectin also was not correlated with fasting glucose concentration (p = 0.421).

Conclusion: The results demonstrated that, regardless of a closely correlation between obesity and insulin resistance, adiponectin role as anti-inflammatory cytokine in FEV1/FVC in asthma patients is independent of insulin resistance. Future studies are necessary for diagnosis insulin resistance role as an asthma risk factor in children or adults.

Keywords

Fulltext

References

1.
The references of this article is available on PDF.

comments