Seroconversion rates after hepatitis-B vaccination in children

Mandana Afsharian; Mohammad Ghaderi; Siavash Vaziri; Zahra  Leghaei; Keighobad Ghadiri; Alireza Janbaksh; Babak Sayad; Feizollah Mansouri; Kourosh Nikzad

Journal of Kermanshah University of Medical Sciences

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Seroconversion rates after hepatitis-B vaccination in children

Author(s):

Mandana Afsharian¹,

Mohammad Ghaderi ²,

Siavash Vaziri ¹,

Zahra Leghaei³,

Keighobad Ghadiri^2,*,

Alireza Janbaksh¹,

Babak Sayad¹,

Feizollah Mansouri¹,

Kourosh Nikzad⁴

1Dept. Of Infectious Disease, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran

2Dept. of Pediatrics, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran

3Dept. of Health of Kermanshah Province, Kermanshah University of Medical Sciences, Kermanshah, Iran

4Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran

Journal of Kermanshah University of Medical Sciences:Vol. 15, issue 6; e78901

Published online:Mar 19, 2012

Article type:Research Article

Received:Apr 11, 2011

Accepted:Jun 28, 2011

How to Cite:Mandana AfsharianMohammad Ghaderi Siavash Vaziri Zahra LeghaeiKeighobad GhadiriAlireza JanbakshBabak SayadFeizollah MansouriKourosh Nikzadet al.Seroconversion rates after hepatitis-B vaccination in children.J Kermanshah Univ Med Sci.15(6):e78901.

Abstract

Background: Hepatitis- B infection is one of the infectious diseases that transmits via blood transfiosion, blood product, injection, mother to fetus and sexual contact. Protective anti hepatitis-B titer are observed in more than 90% of healthy children. The aim of this study was to evaluate seroconversion rates in children who received routine vaccination program.

Methods: A cross sectional study was designed. 196 children who received routine hepatitis-B vaccine (at birth, 2 and 6 months old) were selected. Anti hepatitis-B titer was measured using ELISA method in 6-7 years old children. Data was analyzed using chi-square and fisher exact tests.

Results: 69 % of all participants (98 boys and 98 girls) showed protective antibody titer (71.4% in girl and 67% in boys). There was no significant correlation between sex, weight and BMI and antibody response.

Conclusion: Seroconversion rate after hepatitis–B vaccination was lower than the semilar studies. The etiology of low seroconversion rate needs to do further study in Kermanshah.

Keywords

hepatitis-B

vaccination

children

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