The effect of clofibrate and phototherapy on physiological jaundice in term newborns

Ali Asghar Alipour; Homa Babaei; Sayed amir Masoud Borghaee; Amir Hosein Hashemian; Mahba Azizi

Journal of Kermanshah University of Medical Sciences

Peer-reviewed Medical Quarterly

Current Issue All Issues In Press Accepted Manuscripts Search

Journal Information Boards and Committees Indexing and Listing Sources Journal Metrics Open Peer Review (OPR)Publication Ethics and Malpractice Statement Contact Us Support Reviewer and AE Registration Form

Authors Guide Submit Manuscript

The effect of clofibrate and phototherapy on physiological jaundice in term newborns

Author(s):

Ali Asghar Alipour¹,

Homa Babaei^1,*,

Sayed amir Masoud Borghaee²,

Amir Hosein Hashemian³,

Mahba Azizi¹

1Dept. of Pediatrics, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran

2Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran

3Dept. of Epidemiology and Biostatistics, School of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran

Journal of Kermanshah University of Medical Sciences:Vol. 15, issue 4; e79284

Published online:Nov 19, 2011

Article type:Research Article

Received:Jul 06, 2010

Accepted:Nov 02, 2010

How to Cite:Ali Asghar AlipourHoma BabaeiSayed amir Masoud BorghaeeAmir Hosein HashemianMahba AziziThe effect of clofibrate and phototherapy on physiological jaundice in term newborns.J Kermanshah Univ Med Sci.2011;15(4):e79284.

Abstract

Background: Clofibrate is an effective anti lipid agent that induces glucuronyltransferase could increase bilirubin conjugation. The aim of this study was to evaluate effect of clofibrate on neonatal physiologic jaundice.

Methods: Randomized clinical trial sampling method used and 60 healthy term neonates which were admitted in Imam Reza Hospital of Kermanshah-Iran because of indirect hyperbilirubinemia enrolled into the study. 30 neonates (case group) were treated with single oral dose of clofibrate (100/mg) plus phototherapy and 30 neonates (control group) received only phototherapy. Serum total and direct bilirubin levels were measured at admission, 12 hours later, and then every 24 hours until 96 hours.

Results: There were no significant difference between two groups regarding to gender, age, weight and total serum bilirubin level at the admission. Mean values for total bilirubin of serum in case group 12, 24 and 48 hours after admission were significantly lower than control group (P<0.001). The mean of needed time for phototherapy in case group was significantly less than the control group (P<0.00l).

Conclusion: It seems that clofibrate plus phototherapy is effective for treatment of neonatal physiologic jaundice in healthy term newborns, although further studies are necessary for evaluation of clofibrate safety as a routine treatments.

Keywords

clofibrate

phototherapy

jaundice

Fulltext

References

1.
The references of this article is available on PDF.

comments