Low dose oral theophylline effects on HS-CRP in stable COPD patients


avatar Naseh Sigari 1 , * , avatar Vahid Yousefinejad 2 , avatar Jamal Seidi 3

Dept. of Internal Medicine, School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran
Dept. of Forensic Medicine, Tehran University of Medical Sciences, Tehran, Iran
Dept. of Operating Room, School of Para medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran

how to cite: Sigari N, Yousefinejad V, Seidi J. Low dose oral theophylline effects on HS-CRP in stable COPD patients. J Kermanshah Univ Med Sci. 2011;15(4):e79285.


Background: Low dose theophylline may have some anti-inflammatory effects on COPD patients. This study was conducted to determine the effect of oral low dose theophylline on serum CRP level in patients with stable COPD.
Methods: In this double blind randomized clinical trail study, 50 patients (25 in experimental and 25 in placebo group) were enrolled into the study by randomized blocking method. Serum HS-CRP using ELISA method was measured before and after the study. Data was analyzed using t-test and paired t-test.
Results: There was no significant difference in gender, age, smoking and spirometry variables before study between two groups. Serum HS-CRP level remained the same between two groups before and after the intervention.
Conclusion: More studies with large sample size needed to find anti-inflammatory effect of theophylline on macrophages and neutrophils and their derivative inflammatory materials in COPD patients.



  • 1.

    The references of this article is available on PDF

© 2011, Journal of Kermanshah University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.