Autoimmune thyroid disorder in patient with chronic hepatitis C before treatment

Mehr Ali Rahimi; Babak Sayad; Ahmad Tahamoli Roudsari; Karoun Shahebrahimi; Maria Shirvani; Mansour Rezaei

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Autoimmune thyroid disorder in patient with chronic hepatitis C before treatment

Author(s):

Mehr Ali Rahimi¹,

Babak Sayad²,

Ahmad Tahamoli Roudsari^3,*,

Karoun Shahebrahimi¹,

Maria Shirvani⁴,

Mansour Rezaei⁵

1Dept of Internal Medicine, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran

2Dept. of Infectious Medicine, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran

3Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran

4Hepatitis Research Center, Emam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran

5Dept. of Biostatistics and Epidemiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran

Journal of Kermanshah University of Medical Sciences:Vol. 15, issue 3; e79361

Published online:Sep 19, 2011

Article type:Research Article

Received:May 15, 2010

Accepted:Oct 05, 2010

How to Cite:Mehr Ali RahimiBabak SayadAhmad Tahamoli RoudsariKaroun ShahebrahimiMaria ShirvaniMansour Rezaeiet al.Autoimmune thyroid disorder in patient with chronic hepatitis C before treatment.J Kermanshah Univ Med Sci.15(3):e79361.

Abstract

Background: Creating autoantibodies against thyroid in hepatitis C patients who are being treated with interferon is now recognized for several years. Recently, some studies have claimed that prevalence of autoimmune thyroid disorders in Hepatitis C patients is higher when they are not treated by interferon and/or at the beginning of diagnosis, however the area still remained controversial. In order to analyze autoimmune thyroid disorders in Hepatitis C patients who are not still treated by interferon and compare them with the control group this study has been conducted.

Methods: A Case-Control study including 86 chronic hepatitis C patients before commencing treatment by interferon and 86 healthy volunteer individuals were examined. Data was collected using demographic and clinical variables questionnaires from both groups. FT4, TSH, Anti TPO and Anti TG examinations carried out in both group.

Results: The findings of this study showed increase Anti TPO in 4 cases in 13 case, increased is Anti TG in 5 case, sub clinical hypothyroid, ism sub clinical hyperthyroid in 3 ism and hyperthyroid ism in one case in the case group were observed. There was no significant difference between the case and the control group.

Conclusion: We can conclude that there is no relationship between chronic hepatitis C infection and autoimmune thyroid.

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