Autoimmune thyroid disorder in patient with chronic hepatitis C before treatment

authors:

avatar Mehr Ali Rahimi 1 , avatar Babak Sayad 2 , avatar Ahmad Tahamoli Roudsari 3 , * , avatar Karoun Shahebrahimi 1 , avatar Maria Shirvani 4 , avatar Mansour Rezaei 5

Dept of Internal Medicine, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
Dept. of Infectious Medicine, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran
Hepatitis Research Center, Emam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran
Dept. of Biostatistics and Epidemiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran

how to cite: Rahimi M A, Sayad B, Tahamoli Roudsari A, Shahebrahimi K, Shirvani M, et al. Autoimmune thyroid disorder in patient with chronic hepatitis C before treatment. J Kermanshah Univ Med Sci. 2011;15(3):e79361.

Abstract

Background: Creating autoantibodies against thyroid in hepatitis C patients who are being treated with interferon is now recognized for several years. Recently, some studies have claimed that prevalence of autoimmune thyroid disorders in Hepatitis C patients is higher when they are not treated by interferon and/or at the beginning of diagnosis, however the area still remained controversial. In order to analyze autoimmune thyroid disorders in Hepatitis C patients who are not still treated by interferon and compare them with the control group this study has been conducted.
Methods: A Case-Control study including 86 chronic hepatitis C patients before commencing treatment by interferon and 86 healthy volunteer individuals were examined. Data was collected using demographic and clinical variables questionnaires from both groups. FT4, TSH, Anti TPO and Anti TG examinations carried out in both group.
Results: The findings of this study showed increase Anti TPO in 4 cases in 13 case, increased is Anti TG in 5 case, sub clinical hypothyroid, ism sub clinical hyperthyroid in 3 ism and hyperthyroid ism in one case in the case group were observed.  There was no significant difference between the case and the control group.
Conclusion: We can conclude that there is no relationship between chronic hepatitis C infection and autoimmune thyroid.

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