Determination of Rifampin and Isoniazid resistant mycobacterium tuberculosis in Kermanshah (2006-2008)

authors:

avatar Babak Izadi 1 , avatar Malek Kanani 1 , * , avatar Sedigheh Khazaei 1 , avatar Sayed Hamid Madani 1

Dept. of Pathology. Molecular Pathology Research Center, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
Journal of Kermanshah University of Medical Sciences: Vol.15, issue 2; e79383
published online: July 19, 2011
article type: Brief Report
received: May 31, 2010
accepted: August 03, 2010

how to cite: Izadi B, Kanani M, Khazaei S, Madani S H. Determination of Rifampin and Isoniazid resistant mycobacterium tuberculosis in Kermanshah (2006-2008). J Kermanshah Univ Med Sci. 2011;15(2):e79383. 

Abstract

Tuberculosis is one of the most important infectious diseases and a major cause of morbidity and mortality in developing countries. Multi drug resistant tuberculosis is a new threat, which can result in a high case fatality rate. This study was conducted to define the incidence of multidrug resistant tuberculosis in Kermanshah. ­Antibiogram was performed on­­ PCR-confirmed isolates of mycobacterium tuberculosis by using the proportion method. Eight cases (57.1%) showed resistance to ­1µg/ml Isoniazid­. Resistance to Rifampicin was identified in 46.2% ­of cases.­ This study showed a high rate of single drug and multidrug resistance. We recommend antibiogram for all cases of tuberculosis.

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