Angiogenesis and tumor


avatar Kamran Mansouri 1 , * , avatar Ali Mostafaie 1 , avatar Hamid-Reza Mohammadi-Motlagh 1

Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran

how to cite: Mansouri K , Mostafaie A, Mohammadi-Motlagh H. Angiogenesis and tumor. J Kermanshah Univ Med Sci. 2011;14(4):e79444.


Angiogenesis, the process of new blood vessel formation from existing ones, plays an important role in  the physiologic circumstances such as embryonic development, placenta formation, and wound healing. It is also crucial to progress of pathogenic processes of a variety of disorders, including tumor growth and metastasis. In general, angiogenesis process is a multi-factorial and highly structured sequence of cellular events comprising migration, proliferation and differentiation of endothelial cells and finally vascular formation, maturation and remodeling.Thereby, angiogenesis inhibition as a helping agent to conventional therapies such as chemotherapy and radiation has attracted the scientists’ attentions studying in this field.



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