Effect of heparin infusion on free fatty acids and triglyceride level during submaximal exercise

Mojtaba Izadi; Asghar Zarifyan; Anoush Eghdami; Davood Khorshidi; Hosain Doali

Journal of Kermanshah University of Medical Sciences

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Effect of heparin infusion on free fatty acids and triglyceride level during submaximal exercise

Author(s):

Mojtaba Izadi^1,*,

Asghar Zarifyan¹,

Anoush Eghdami¹,

Davood Khorshidi¹,

Hosain Doali¹

1Dept. of Athletic Sciences, Islamic Azad Uversity, Saveh, Iran

Journal of Kermanshah University of Medical Sciences:Vol. 14, issue 2; e79510

Published online:Sep 19, 2010

Article type:Research Article

Received:Aug 08, 2009

Accepted:Dec 22, 2009

How to Cite:Izadi M, Zarifyan A, Eghdami A, Khorshidi D, Doali H. Effect of heparin infusion on free fatty acids and triglyceride level during submaximal exercise.J Kermanshah Univ Med Sci.2010;14(2):e79510.

Abstract

Background: Fatty acids are an important source of energy for muscle contraction, particularly during longtime exercise. The objective of this clinical trail study was to determination effect of heparin infusion on lipids metabolism during submaximal exercise.

Methods: Forty boy students performed Astrand ergometery protocol for 20-minute on cycle ergometer in two separate occasions. Stage1 without any heparin administration and stage 2 with heparin (10000 U) and lactose infusion were performed in order of experimental and control groups 30-minute prior to test. A Blood sample was obtained immediately followed up exercise for purpose of plasma free fatty acid (FFA), triglyceride (TG) measurement. T test was used to determine significant differences between variables in two groups.

Results: Heparin infusion lead to significant increase in FFA and decrease in TG during exercise (P<0.05(. The resting heart rate decreased and VO2max increased significantly in heparin infusion group (P<0.05(. There were no significant changes of FFA or TG variables in lactose infusion control group.

Conclusion: Heparin infusion leads to increase in fat oxidation substrates and aerobic capacity that probably associated with decreasing in glucose consumption and carbohydrate oxidation. Simultaneous measurement of FFA and carbohydrate oxidation substrates is necessary to determine precise effect of heparin on endurance performance during exercise.

Keywords

endurance performance

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