The effect of Omeprazol and Ranitidine on gastric acidity in ICU patients

Ghobad Salimi; Sayed Jafar Navabi; Nader Jangi Oskoie

Journal of Kermanshah University of Medical Sciences

Peer-reviewed Medical Quarterly

Current Issue All Issues In Press Accepted Manuscripts Search

Journal Information Boards and Committees Indexing and Listing Sources Journal Metrics Open Peer Review (OPR)Publication Ethics and Malpractice Statement Reviewer and AE Registration Form Contact Us Support

Authors Guide Submit Manuscript

The effect of Omeprazol and Ranitidine on gastric acidity in ICU patients

Author(s):

Ghobad Salimi^1,*,

Sayed Jafar Navabi¹,

Nader Jangi Oskoie¹

1Dept. of Internal Ward, School of Medicine Kermanshah University of Medical Sciences, Kermanshah, Iran

Journal of Kermanshah University of Medical Sciences:Vol. 13, issue 4; e79580

Published online:Mar 19, 2010

Article type:Research Article

Received:May 19, 2009

Accepted:Sep 22, 2009

How to Cite:Ghobad SalimiSayed Jafar NavabiNader Jangi OskoieThe effect of Omeprazol and Ranitidine on gastric acidity in ICU patients.J Kermanshah Univ Med Sci.13(4):e79580.

Abstract

Background: ICU patients especially those under mechanical ventilation or with a history of coagulation disorders are at the risk of stress ulcer development and related GI bleeding. Typically H2 blockers administration showed prophylactic role to control gastric acidity. Preliminary studies have shown that administration of intravenous Omeperazol is effective. The object of this study was to compare the effect of oral rout administration of Omeprazol with intravenous Ranitidine on gastric pH.

Methods: In this experimental study 40 ICU patients under mechanical ventilation allocated into same conditions and matched Ranitidine and Omeprazol groups (20 subjects in each group). First group received 50 mg intravenous Ranitidine twice per day and the second group received 40 mg oral Omeperazol once a day. The gastric acidity was monitored using Chorning method. Gastric pH was determined before administration and three times per day after drugs administration then followed for three consequent days. Data was analysed using T-test and SPSS software.

Results: The mean gastric pH in the Ranitidin group was 2.07±0.79 before and 2.80±0.85 after drug administration. In the Omeperazol group gastric pH was 2.01±1.52 before and 3.90± 1.52 after drug administration. The oral Omeperazol administration was significantly effective than intravenous Ranitidine administration (p <0.005).

Conclusion: Our data suggest that in critically ill patients oral rout administration of Omeperazol is more effective than intravenous H2 blocker (Ranitidine) to decrease gastric acidity and may prevent from stress ulcer.

Keywords

Fulltext

References

1.
The references of this article is available on PDF.

comments