The effect of Iron Supplements on serum lipids profile of patients with iron deficiency

Mmohammad Reza Mortazavizade; Ramin Sami; Hadi Mottaghipisheh; Masoud Ehtesham

Journal of Kermanshah University of Medical Sciences

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The effect of Iron Supplements on serum lipids profile of patients with iron deficiency

Author(s):

Mmohammad Reza Mortazavizade^1,*,

Ramin Sami¹,

Hadi Mottaghipisheh ²,

Masoud Ehtesham¹

1Dept. of Internal Medicine, School of Medicine, Shahid Sadooghi University of Medical Sciences, Yazd, Iran

2School of Medicine, Shahid Sadooghi University of Medical Sciences, Yazd, Iran

Journal of Kermanshah University of Medical Sciences:Vol. 13, issue 1; e79828

Published online:Jun 19, 2009

Article type:Research Article

Received:Oct 22, 2007

Accepted:Apr 28, 2009

How to Cite:Mmohammad Reza MortazavizadeRamin SamiHadi Mottaghipisheh Masoud EhteshamThe effect of Iron Supplements on serum lipids profile of patients with iron deficiency.J Kermanshah Univ Med Sci.13(1):e79828.

Abstract

Background: A close relationship has been reported between level of serum iron and ischemic heart diseases which is either brought about through direct effect of serum iron on myocardial cells or as an indirect result of elevated serum lipid profile. A widespread use of iron supplements has been observed due to the high prevalence of iron deficiency anemia. Yet an elevated serum lipid is strongly related with several major complications. This study examines the serum lipid profile before and after treatment with iron supplements.

Methods: In this clinical trial, 200 patients with iron deficiency were treated with iron supplements for a period of 3 months. Hb, Ferritin, serum iron, TIBC and lipid profile were measured 1 and 3 month after the treatment. Data were then analyzed using paired t test.

Results: A total of 200 female patients were recruited. Hb level, Ferritin and SI/TIBC increased significantly after 3 months therapy (p-value<0.001). Cholesterol, LDL, HDL increased significantly independently of age, initial Hb level, Ferritin and SI/TIBC (p-value< 0.05). There was also a significant increase in Triglyceride with no dependency to Ferritin, Hb and SI/TIBC. However, the elevation was related to age.

Conclusion: Treatment with iron supplement leads to elevation of TG, CHOL, HDL, and LDL level after three months.

Keywords

iron deficiency

iron supplement

serum lipids

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