Serum Antioxidant Markers in Patients with Major and Minor  B-thalassemia

Jafar Nowrouz-Zadeh; E Eftekhar; M Chiani; S Hejazi

Journal of Kermanshah University of Medical Sciences

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Serum Antioxidant Markers in Patients with Major and Minor B-thalassemia

Author(s):

Jafar Nowrouz-Zadeh ^1,*,

E Eftekhar¹,

M Chiani¹,

S Hejazi¹

1Iran

Journal of Kermanshah University of Medical Sciences:Vol. 12, issue 1; e80108

Published online:Jun 19, 2008

Article type:Research Article

Received:Aug 19, 2007

Accepted:Apr 22, 2008

How to Cite:Jafar Nowrouz-Zadeh E EftekharM ChianiS HejaziSerum Antioxidant Markers in Patients with Major and Minor B-thalassemia.J Kermanshah Univ Med Sci.12(1):e80108.

Abstract

Materials & Methods: Patients with major b-thalassemia or individuals with minor thalassemia (Age range: 2-12 years and 29-46 years, respectively; n=20 each) and 20 age and sex matched control subjects were recruited. Serum glutathione (GSH) , superoxide dismutase and catalase (CAT) were determined spectrophotometrically. Data were analysed by t-test.

Results: Glutathione levels were markedly lower in patients with b-thalassemia major than in the controls (P<0.05) whilst no differences were seen in either in the activities of catalase or superoxide dismutase. On the contrary, no differences were observed in individuals with minor thalassemia .When patients with major b-thalassemia and individuals with minor thalassemia were compared a marked reduction in GSH levels and increased in CAT activity were noted in the patient group (P<0.05).

Conclusion: The data implies disturbance in antioxidant system in patients with major b-thalassemia as measured by a marked reduction of serum glutathione as the first line of defence against free radical attacks and increased in the activity of CAT. This condition eventually leads to cellular tissue damage. Antioxidant therapy may, therefore, prove useful in protecting against tissue damage.

Keywords

Major Beta-thalassemia

Minor Beta-thalassemia

Antioxidant

Iron overload

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