Abstract
Introduction and Objective: Alkylbenzene sulfonate is used as surfactant and, being discarded into rivers, it acts as an environmental pollutant. The enzyme AMP deaminase may be potentially useful in delineating the possible mechanisms of biological toxicity of alkylbenzene sulfonate.
Materials and Methods: We studied the effects of alkylbenzene sulfonate on rat's brain AMP deaminase activity by measuring ( with spectrophotometry) the enzyme activity with and without exposure to 5-10 micromole concentrations of alkylbenzene sulfonate, using 30 specimens in each study arm.
Results: Enzyme activity in presence and absence of exposure to alkylbenzene sulfonate was 92.85±8.52 and 18.31±2.45 nmol/min/gr brain protein, respectively.
Discussion and Conclusions: Alkylbenzene sulfonate may inhibit AMP deaminase by reacting to its active site. Our results may be used to understand the toxicity of alkylbenzene sulfonate.
Keywords
Alkylbenzene sulfonate AMP deaminase environmental pollutant.
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© 2002, Journal of Kermanshah University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.