Effects of alkylbenzene sulfonate on rat's brain  AMP deaminase activity

D Ghoojagh; AM Ghazi Mirsaeed; M Ahanjan

Journal of Kermanshah University of Medical Sciences

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Effects of alkylbenzene sulfonate on rat's brain AMP deaminase activity

Author(s):

D Ghoojagh^1,*,

AM Ghazi Mirsaeed¹,

M Ahanjan¹

1Iran

Journal of Kermanshah University of Medical Sciences:Vol. 6, issue 2; e81004

Published online:Sep 19, 2002

Article type:Research Article

Received:Apr 11, 2002

Accepted:Sep 11, 2002

How to Cite:Ghoojagh D, Ghazi Mirsaeed A, Ahanjan M. Effects of alkylbenzene sulfonate on rat's brain AMP deaminase activity.J Kermanshah Univ Med Sci.2002;6(2):e81004.

Abstract

Introduction and Objective: Alkylbenzene sulfonate is used as surfactant and, being discarded into rivers, it acts as an environmental pollutant. The enzyme AMP deaminase may be potentially useful in delineating the possible mechanisms of biological toxicity of alkylbenzene sulfonate.

Materials and Methods: We studied the effects of alkylbenzene sulfonate on rat's brain AMP deaminase activity by measuring ( with spectrophotometry) the enzyme activity with and without exposure to 5-10 micromole concentrations of alkylbenzene sulfonate, using 30 specimens in each study arm.

Results: Enzyme activity in presence and absence of exposure to alkylbenzene sulfonate was 92.85±8.52 and 18.31±2.45 nmol/min/gr brain protein, respectively.

Discussion and Conclusions: Alkylbenzene sulfonate may inhibit AMP deaminase by reacting to its active site. Our results may be used to understand the toxicity of alkylbenzene sulfonate.

Keywords

Alkylbenzene sulfonate

AMP deaminase

environmental pollutant.

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Author(s):

D Ghoojagh:[PubMed][Scholar]
AM Ghazi Mirsaeed:[PubMed][Scholar]
M Ahanjan:[PubMed][Scholar]