Comparing the anti-type 2 collagen antibody titer  in rheumatoid factor negative vs. rheumatoid factor positive sera

F Karimi; N Firoozmanesh

Journal of Kermanshah University of Medical Sciences

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Comparing the anti-type 2 collagen antibody titer in rheumatoid factor negative vs. rheumatoid factor positive sera

Author(s):

F Karimi^1,*,

N Firoozmanesh¹

1Iran

Journal of Kermanshah University of Medical Sciences:Vol. 6, issue 2; e81006

Published online:Sep 19, 2002

Article type:Research Article

Received:Apr 11, 2002

Accepted:Sep 11, 2002

How to Cite:Karimi F, Firoozmanesh N. Comparing the anti-type 2 collagen antibody titer in rheumatoid factor negative vs. rheumatoid factor positive sera.J Kermanshah Univ Med Sci.2002;6(2):e81006.

Abstract

Introduction and Objectives: This study was done to determine the anti-type 2 collagen (anti cII) antibody titer in rheumatoid factor negative(RF-) vs. rheumatoid factor positive(RF+) sera.

Materials and Methods: 77 RF+ and 221 RF- sera were examined for presence and titer of anti-type 2 collagen antibody, using the tannic acid hemagglutination method.

Results: Anti cII antibody was found in 67.5% and 57.9% of RF+ and RF- cases, respectively.There was no significant difference between RF- vs. RF+ sera regarding the presence of anti cII antibody . However, there was a significant difference (p<0.001) between RF- vs. RF+ sera regarding the titer of anti cII antibody, with significantly higher antibody levels in RF+ sera.

Discussion and Conclusions: We suggest further studying the correlation between anti cII antibody, RF, and disease severity in rheumatoid arthritis is worthwhile.

Keywords

Collagen

autoimmunity

rheumatoid factor

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Author(s):

F Karimi:[PubMed][Scholar]
N Firoozmanesh:[PubMed][Scholar]