Abstract
Introduction and Objectives: This study was done to determine the anti-type 2 collagen (anti cII) antibody titer in rheumatoid factor negative(RF-) vs. rheumatoid factor positive(RF+) sera.
Materials and Methods: 77 RF+ and 221 RF- sera were examined for presence and titer of anti-type 2 collagen antibody, using the tannic acid hemagglutination method.
Results: Anti cII antibody was found in 67.5% and 57.9% of RF+ and RF- cases, respectively.There was no significant difference between RF- vs. RF+ sera regarding the presence of anti cII antibody . However, there was a significant difference (p<0.001) between RF- vs. RF+ sera regarding the titer of anti cII antibody, with significantly higher antibody levels in RF+ sera.
Discussion and Conclusions: We suggest further studying the correlation between anti cII antibody, RF, and disease severity in rheumatoid arthritis is worthwhile.
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© 2002, Journal of Kermanshah University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.