Abstract
Introduction and Objectives: Since cyanide is a strong inhibitor of cytochrome oxidase and metabolism , we need to know whether it is useful in increasing cardiac resistance to ischemia.
Materials and Methods: Male rats received either 1.7mg/kg potassium cyanide or normal saline transperitoneally for 35 days. Then, isolated hearts were examined at baseline, during ischemia and after return to normal perfusion state..
Results: Coronary blood flow, left ventricular pressure and contractility (dp/dt) were similar in two groups, but at ischemic state (p<0.005) and at recovery to normal state(p<0.05) there were statistically significant differences in left ventricular pressure and contractility (dp/dt) between the two groups.
Discussion and Conclusions: It seams that cyanide induce cardiac resistance to ischemic effects in rats.
Keywords
cyanide ischemia isolated heart left ventricular pressure cardiac protection
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© 2002, Journal of Kermanshah University of Medical Sciences. This open-access article is available under the Creative Commons Attribution-NonCommercial 4.0 (CC BY-NC 4.0) International License (https://creativecommons.org/licenses/by-nc/4.0/), which allows for the copying and redistribution of the material only for noncommercial purposes, provided that the original work is properly cited.