Efficacy of Hydroxy urea in Thalassemia intermedia

authors:

avatar MA Ehsaani 1 , * , avatar AA HedaayatiAsl 1 , avatar AR Baagheri 1

Iran

how to cite: Ehsaani M, HedaayatiAsl A, Baagheri A. Efficacy of Hydroxy urea in Thalassemia intermedia. J Kermanshah Univ Med Sci. 2002;6(3):e81014.

Abstract

Introduction and Objectives: There is some controversy over the clinical efficacy of  Hydroxy urea in Thalassemia intermedia.
Materials and Methods: Therapeutic efficacy of  Hydroxy urea was evaluated in 16 patients with thalassemia intermedia, by measuring total hemoglobin and hemoglobin F levels before and 6months after treatment with Hydroxy urea (20mg/kg/day).
 Results: Mean increases in total hemoglobin and hemoglobin F levels 6mo after treatment with Hydroxy urea were 1.47±1.12gm/dl and 1.43±1.12 gm/dl, respectively. The most common mutation was found to be  IV S II-I betaglobin. 
 Discussion and Conclusions:  Use of Hydroxy urea in thalassemia intermedia is associated with increases in total hemoglobin and hemoglobin F levels.

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