Immune response to hepatitis B vaccine in health care workers of Kermanshah


avatar AR Janbakhsh 1 , * , avatar H Hatami 1 , avatar B Sayad 1 , avatar P Aieni 1 , avatar AH Hashemian 1


how to cite: Janbakhsh A, Hatami H, Sayad B, Aieni P, Hashemian A. Immune response to hepatitis B vaccine in health care workers of Kermanshah. J Kermanshah Univ Med Sci. 2003;7(1):e81203.


Background & Objectives: hepatitis B is a major health problem in Iran. Although seroconversion in vaccinated persons is estimated to be more than 90%, immune response to hepatitis B vaccine have been reported to be varied in different studies. This study was done to assess the vaccine effects in health care workers (HCWs).
Materials and Methods: I this descriptive, cross sectional study, HBSAb titer in 138 HBCAb negative, vaccinated HCWs in 10 health care centers was assessed using ELISA method. Of 138 HCWs, 60.1% were females and 39.9 males.
Results: 69.9% developed protective immune response. Age was a significant factor in responsiveness. Sex, weight, and last vaccination time had no significant role.
Discussion: In our study, rate of immune response to hepatitis B was low. Thus, revaccination may be necessary for nonresponders. We suggest that cost-effectiveness of the Heberbiovac HB vaccine should be re-evaluated in high risk groups.


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© 2003, Journal of Kermanshah University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.