The hemodynamic effect of captopril on the left to right shunt in VSD

G Solgi; Z Jalili; M Masoumi; F Sabzi; M Hemati

Journal of Kermanshah University of Medical Sciences

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The hemodynamic effect of captopril on the left to right shunt in VSD

Author(s):

G Solgi^1,*,

Z Jalili¹,

M Masoumi¹,

F Sabzi¹,

M Hemati¹

1Iran

Journal of Kermanshah University of Medical Sciences:Vol. 7, issue 2; e81209

Published online:Sep 19, 2003

Article type:Research Article

Received:Apr 12, 2003

Accepted:Aug 15, 2003

How to Cite:G SolgiZ JaliliM MasoumiF SabziM HematiThe hemodynamic effect of captopril on the left to right shunt in VSD.J Kermanshah Univ Med Sci.7(2):e81209.

Abstract

Background and Objective : Ventricular septal defect (VSD) is the most common pediatric congenital heart diseass (CHD ). The main complications of moderate to large size VSD are recurrent respiratory tract infection ,congestive heart failure, Failure to thrive, and pulmonary hypertension. These complications are the results of large left to right shut. We evaluated the effect of captopril on moderate to large size VSD.

Material and methods: Twenty patients ( five girls and fifteen boys, mean age 6.5±2.8 years) were studied .Using a new echocardiographic technique we measured Qp/Qs ratio befor and after treatment with Captopril (3 mg/kg/24hr for three days).

Results: After treatment with Captopril, Qp/Qs ratio decreased from 2.4 ± 0.59 to 1.7± 0.46 after treatment. Blood pressure decreased from 104±12.mmHg to 83±9 mmhg.(p<0.001)

Discussion: Captopril can decrease left to right shunt significantly in patients with moderate to large size VSD .Long term use of captopril may results in clinical improvement and delay the need for surgical correction .

Keywords

VSD

left to right shunt

Captopril

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