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The hemodynamic effect of captopril on the left to right shunt in VSD


avatar G Solgi 1 , * , avatar Z Jalili 1 , avatar M Masoumi 1 , avatar F Sabzi 1 , avatar M Hemati 1

1 Iran

How to Cite: Solgi G, Jalili Z, Masoumi M, Sabzi F, Hemati M. The hemodynamic effect of captopril on the left to right shunt in VSD. J Kermanshah Univ Med Sci. 2003;7(2):e81209.


Journal of Kermanshah University of Medical Sciences: 7 (2); e81209
Published Online: September 19, 2003
Article Type: Research Article
Received: April 12, 2003
Accepted: August 15, 2003


Background and Objective : Ventricular septal defect (VSD) is the most common pediatric congenital heart diseass (CHD ). The main complications of  moderate to large size VSD are recurrent respiratory tract infection ,congestive heart failure, Failure to thrive, and  pulmonary hypertension. These complications are the results of     large left to right shut. We evaluated the effect of captopril on moderate to large size VSD.
Material and methods: Twenty patients ( five girls and fifteen boys, mean age  6.5±2.8  years)   were studied .Using a new echocardiographic technique we measured Qp/Qs ratio befor and after treatment with Captopril (3 mg/kg/24hr for three days).  
Results: After treatment with Captopril, Qp/Qs ratio decreased from 2.4 ± 0.59 to 1.7± 0.46 after treatment. Blood pressure decreased from 104±12.mmHg to 83±9 mmhg.(p<0.001)
Discussion:  Captopril can decrease left to right shunt significantly in   patients with moderate to large size VSD .Long term use of captopril may results in clinical improvement and  delay the need for surgical correction .


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© 2003, Journal of Kermanshah University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.