Correlation of premature coronary artery disease in parents with dyslipidemia in their children

M Masoumi; Z Jalili; F Sabzi; B moradi; G Abdoli; F Siah; F Mozafari; P Moradi

Journal of Kermanshah University of Medical Sciences

Peer-reviewed Medical Quarterly

Current Issue All Issues In Press Accepted Manuscripts Search

Journal Information Boards and Committees Indexing and Listing Sources Journal Metrics Open Peer Review (OPR)Publication Ethics and Malpractice Statement Reviewer and AE Registration Form Contact Us Support

Authors Guide Submit Manuscript

Correlation of premature coronary artery disease in parents with dyslipidemia in their children

Author(s):

M Masoumi^1,*,

Z Jalili¹,

F Sabzi¹,

B moradi¹,

G Abdoli¹,

F Siah¹,

F Mozafari¹,

P Moradi¹

1Iran

Journal of Kermanshah University of Medical Sciences:Vol. 7, issue 2; e81210

Published online:Sep 19, 2003

Article type:Research Article

Received:Apr 12, 2003

Accepted:Aug 15, 2003

How to Cite:M MasoumiZ JaliliF SabziB moradiG AbdoliF SiahF MozafariP Moradiet al.Correlation of premature coronary artery disease in parents with dyslipidemia in their children.J Kermanshah Univ Med Sci.7(2):e81210.

Abstract

Background and Objective : Recognition and modification of risk factors of coronary artery disease (CAD) has obtained great attention. Early recognition of the risk factors, especially in youth, may decrease incidence and complications of CAD. Dyslipidemia is a risk factor of CAD. We studied the correlation of dyslipidemia in parents and their children.

Material and methods:In a cross sectional study, 312 patients , all younger than 55, were evaluated. These patients underwent coronary angiography in Imam Ali hospital during the year 1380. According to the angiographic findings, the patients were divided into coronary and non-coronary groups. Fasting blood samples were obtained from patients, their spouses, and their children to determine the serum levels of total cholesterol, HDL, LDL, and triglyceride. Statistical analysis was done using t test and
χ² test.

Results: Compared with the children of the non-coronary patients, LDL was significantly higher in the children of the coronary patients (p<0.014). No significant difference was found in other lipids among the children. Mixed results were obtained when comparing various age groups in children. There was a significant correlation between serum LDL of the spouses of the coronary patients and their children (p<0.032). Mixed results were obtained when comparing the correlation of other lipids in various age groups of spouses and children.

Discussion: Compared with previous reports, we found abnormally high serum lipid levels in the children of the coronary patients. There is a significant correlation between the parents' CAD and their children's dyslipidemia, especially children of younger than 12. There is no simple, linear correlation between risk factors of CAD in parents and their children. Considering the possible influence of genetic factors, we suggest that more studies should be done on this subject.

Keywords

Dyslipidemia

premature coronary artery disease

parents and children

Fulltext

The full text of this article is available on PDF

comments