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Journal of Kermanshah University of Medical Sciences
Peer-reviewed Medical Quarterly
e-ISSN 2588-2570
p-ISSN 2588-2562
The Effect of some Flavonoids on in-vitro Non-enzymatic Glycosylation of Proteins
Authors
1Iran
Published online:Jun 19, 2004
Article type:Research Article
Received:Jan 05, 2004
Accepted:May 10, 2004
How to Cite:Asgary S, Naderi G, Gharipoor M. The Effect of some Flavonoids on in-vitro Non-enzymatic Glycosylation of Proteins. J Kermanshah Univ Med Sci. 2004;8(1):e81306. doi:
Abstract
Introduction: Non-enzymatic glycosylation of proteins which is the major cause of diabetic complications, cardiovascular diseases retinopathy, nephropathy and neuropathy can effectively be inhibted by antioxidants.
Materials and Method: The antioxidant effects of several flavonoids, such as rutin, kaempferol, quercetin, apigenin, naringin, morin and biochanin A were studied on glycosylation of insulin, hemoglobin and albuminin In-vitro.
Optimal glucose concentration as well as incubation time were determined and inhibition percentage of the proteins were measured at three different concentrations (0.5,5 and 10 μg/ml) using spectrophotometric method.
Results: This study showed that biochanin A has potent antioxicant effects as it inhibits glycosylation of hemoglobin insulin and albumin by 100%, 60% and 100% respectively.Apigenin is also inhibits albumin glycosylation by 100%.
Conclusion: As potent antioxidant effects are induced by flavenoedes, preventive effects of some plants containing the flavonoids on diabetic complication is expected.
Copyright
© 2004, Journal of Kermanshah University of Medical Sciences. This open-access article is available under the Creative Commons Attribution-NonCommercial 4.0 (CC BY-NC 4.0) International License (https://creativecommons.org/licenses/by-nc/4.0/), which allows for the copying and redistribution of the material only for noncommercial purposes, provided that the original work is properly cited.
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