Abstract
Context: Short‑term exercise can increase cardiorespiratory function, hemodynamic function, and quality of life in patients with coronary artery bypass graft (CABG).
Aims: The aim of this study was the evaluation of combination training program influence on the placental growth factor (PIGF) and vascular endothelial growth factor receptor 1 (VEGFR‑1) indicators among CABG patients.
Setting and Design: The study method was semi‑experimental; the statistical population was some patients who had heart disease, after CABG at Babol city hospitals, Iran.
Materials and Methods: 16 patients were selected by convenience sampling method.The expression levels of the PIGF and VEGFR‑1 genes were measured by the Real Time PCR method.
Statistical Analysis Used: The covariance analysis method and the dependent t‑test were used.
Results: The results showed that changes in PIGF and VEGFR‑1 gene expression in the experimental group had a significant decrease in the posttest stage compared to the pretest stage; While changes in PIGF and VEGFR‑1 gene expression in the control group were not significantly different in the posttest stage compared to the pretest stage; also, data analysis showed that changes in gene expression of PIGF and VEGFR‑1 factors had a significant decrease in the experimental group compared to the control group.
Conclusion: The study results showed 8 weeks of combination exercises among the experimental group had a significant decrease in the expression levels of PIGF and VEGFR1 genes among CABG patients compared to the control group. Physical activity may decrease PIGF levels, which is an important factor in oxidative stress and inflammation.
Aims: The aim of this study was the evaluation of combination training program influence on the placental growth factor (PIGF) and vascular endothelial growth factor receptor 1 (VEGFR‑1) indicators among CABG patients.
Setting and Design: The study method was semi‑experimental; the statistical population was some patients who had heart disease, after CABG at Babol city hospitals, Iran.
Materials and Methods: 16 patients were selected by convenience sampling method.The expression levels of the PIGF and VEGFR‑1 genes were measured by the Real Time PCR method.
Statistical Analysis Used: The covariance analysis method and the dependent t‑test were used.
Results: The results showed that changes in PIGF and VEGFR‑1 gene expression in the experimental group had a significant decrease in the posttest stage compared to the pretest stage; While changes in PIGF and VEGFR‑1 gene expression in the control group were not significantly different in the posttest stage compared to the pretest stage; also, data analysis showed that changes in gene expression of PIGF and VEGFR‑1 factors had a significant decrease in the experimental group compared to the control group.
Conclusion: The study results showed 8 weeks of combination exercises among the experimental group had a significant decrease in the expression levels of PIGF and VEGFR1 genes among CABG patients compared to the control group. Physical activity may decrease PIGF levels, which is an important factor in oxidative stress and inflammation.
Keywords
Coronary artery bypass graft patients Combination training program Placental growth factor Vascular endothelial growth factor receptor 1
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