The effect of combination training program on the expression of placental growth factor and vascular endothelial growth factor receptor 1 indicators among coronary artery bypass graft patients

How to Cite:Sara BakhtiyarAlireza BarariAhmad AbdiThe effect of combination training program on the expression of placental growth factor and vascular endothelial growth factor receptor 1 indicators among coronary artery bypass graft patients.J Nurs Midwifery Sci.8(1):e140761.https://doi.org/10.4103/jnms.jnms_119_20.

Abstract

Context: Short‑term exercise can increase cardiorespiratory function, hemodynamic function, and quality of life in patients with coronary artery bypass graft (CABG).
Aims: The aim of this study was the evaluation of combination training program influence on the placental growth factor (PIGF) and vascular endothelial growth factor receptor 1 (VEGFR‑1) indicators among CABG patients.
Setting and Design: The study method was semi‑experimental; the statistical population was some patients who had heart disease, after CABG at Babol city hospitals, Iran.
Materials and Methods: 16 patients were selected by convenience sampling method.The expression levels of the PIGF and VEGFR‑1 genes were measured by the Real Time PCR method.
Statistical Analysis Used: The covariance analysis method and the dependent t‑test were used.
Results: The results showed that changes in PIGF and VEGFR‑1 gene expression in the experimental group had a significant decrease in the posttest stage compared to the pretest stage; While changes in PIGF and VEGFR‑1 gene expression in the control group were not significantly different in the posttest stage compared to the pretest stage; also, data analysis showed that changes in gene expression of PIGF and VEGFR‑1 factors had a significant decrease in the experimental group compared to the control group.
Conclusion: The study results showed 8 weeks of combination exercises among the experimental group had a significant decrease in the expression levels of PIGF and VEGFR1 genes among CABG patients compared to the control group. Physical activity may decrease PIGF levels, which is an important factor in oxidative stress and inflammation.

Keywords

Coronary artery bypass graft patients

Combination training program

Placental growth factor

Vascular endothelial growth factor receptor 1

Fulltext

Full-text is available in PDF format.

comments

Crossmark

Checking

Share on

Comments

Number of Comments:0

Cited by

CrossRef 0

Metrics

Get Permission (article level)

Purchasing Reprints

Copyright Clearance Center (CCC) handles bulk orders for article reprints for Brieflands. To place an order for reprints, please click here ( https://www.copyright.com/landing/reprintsinquiryform/ ). Clicking this link will bring you to a CCC request form where you can provide the details of your order. Once complete, please click the ‘Submit Request’ button and CCC’s Reprints Services team will generate a quote for your review.

Search Relations

Author(s):

Sara Bakhtiyar:[PubMed][Scholar]
Alireza Barari:[PubMed][Scholar]
Ahmad Abdi:[PubMed][Scholar]