Necrotizing autoimmune myopathy: Muscle weakness due to atorvastatin

2Department of Reproductive Health and Midwifery, Sexual and Reproductive Health Research Center, Mazandaran University of Medical Sciences, Sari, Iran

Journal of Nursing and Midwifery Sciences:Vol. 5, issue 2; 74-77

Published online:Nov 29, 2018

Article type:Case Report

Received:Jul 31, 2018

Accepted:Sep 29, 2018

How to Cite:Leila PakdelJila GanjiNecrotizing autoimmune myopathy: Muscle weakness due to atorvastatin.J Nurs Midwifery Sci.5(2):e141188.https://doi.org/10.4103/jnms.jnms_17_18.

Abstract

Statins are medications with great use. One of the side effects of medications is myopathy. In some case, statins switch on, a process of autoimmune system which will not terminate with discontinuation of statins. Necrotizing autoimmune myopathy (NAM) is a subgroup of inflammatory myopathies characterized pathologically by necrotic muscle fibers with absent or minimal inflammation. The purpose of this study was to describe NAM in a patient undergoing treatment with atorvastatin for an extended period, diagnosis of the disease process, treatment, and resolution of symptoms. The case presented in this paper is about 72-year-old woman who showed continued general weakness even though she stopped taking atorvastatin. This patient also had elevated creatine kinase and aldolase. Myopathy confirmed by muscle biopsy. She was treated with intravenous immune globulin (IVIG) and pulse of methyl prednisolone and followed with high dose of steroid and azathioprine. Our case report illustrates the importance of early recognition of NAM and that the treatment with immediately administer IVIG, pulse of methylprednisolone, and high dose of steroid can result in complete recovery.

Keywords

Atorvastatin

Autoimmune myopathy

Necrosis

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Author(s):

Leila Pakdel:[PubMed][Scholar]
Jila Ganji:[PubMed][Scholar]