Cytotoxic and Apoptogenic Properties of 2-Phenylthiazole-4-Carboxamide Derivatives in Human Carcinoma Cell Lines

Hanifeh Nazari Tarhan; LEILA HOSSEINZADEH; Alireza Aliabadi; Babak Gholamine; Alireza Foroumadi

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Cytotoxic and Apoptogenic Properties of 2-Phenylthiazole-4-Carboxamide Derivatives in Human Carcinoma Cell Lines

Author(s):

Hanifeh Nazari Tarhan¹,

LEILA HOSSEINZADEH^2,*,

Alireza Aliabadi³,

Babak Gholamine²,

Alireza Foroumadi⁴

1Students Research Committee, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Ira

2Department of Toxicology and Pharmacology Medical services, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran

3Department of Medicinal Chemistry, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran

4Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran

Journal of Reports in Pharmaceutical Sciences:Vol. 1, issue 1; 1-6

Published online:Feb 22, 2012

Article type:Research Article

Received:Jan 13, 2012

Accepted:Feb 08, 2012

How to Cite:Hanifeh Nazari TarhanLEILA HOSSEINZADEHAlireza AliabadiBabak GholamineAlireza ForoumadiCytotoxic and Apoptogenic Properties of 2-Phenylthiazole-4-Carboxamide Derivatives in Human Carcinoma Cell Lines.J Rep Pharm Sci.1(1):e146007.

Abstract

Apoptosis, or programmed cell death, is an essential physiological process that plays a critical role in development and tissue homeostasis. Caspases, a family of cysteine-dependent aspartatedirected proteases, play a critical role in the initiation and execution of apoptosis. In this study, cytotoxicity and apoptogenic effect of 2-phenyl 4-carboxamide derivatives were evaluated in SKNMC (human neuroblastoma), MCF-7 (human breast adenocarcinoma) and HT-29 (human colon cancer) cell lines. Cell viability was determined by MTT assay. Also, activation of caspase-3 was evaluated by spectrophotometry. The overall cytotoxicity profiles of derivatives demonstrated that the HT-29 cell line has more sensitivity respect to other cell lines. Moreover, our observations indicated that 3-F and 2-F derivatives and 4-Cl derivative increased caspase-3 activation in three carcinoma cell line compared to control. Collectively, these findings suggest that these derivatives are able to induce apoptosis in cancer cell lines.

Keywords

2-phenylthiazole-4-carboxamide derivatives

Apoptosis

Caspase-3

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