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Journal of Reports in Pharmaceutical Sciences
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Cytotoxic and Apoptogenic Properties of 2-Phenylthiazole-4-Carboxamide Derivatives in Human Carcinoma Cell Lines
Author(s):
Hanifeh Nazari Tarhan1, LEILA HOSSEINZADEH2,*, Alireza Aliabadi3, Babak Gholamine2, Alireza Foroumadi41Students Research Committee, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Ira
2Department of Toxicology and Pharmacology Medical services, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran
3Department of Medicinal Chemistry, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran
4Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
*Corresponding Author: Corresponding author: Department of Toxicology and Pharmacology Medical services, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran. Email:[email protected]
Published online:Feb 22, 2012
Article type:Research Article
Received:Jan 13, 2012
Accepted:Feb 08, 2012
How to Cite:Nazari Tarhan H, HOSSEINZADEH L, Aliabadi A, Gholamine B, Foroumadi A. Cytotoxic and Apoptogenic Properties of 2-Phenylthiazole-4-Carboxamide Derivatives in Human Carcinoma Cell Lines. J Rep Pharm Sci. 2012;1(1):e146007. doi:
Abstract
Apoptosis, or programmed cell death, is an essential physiological process that plays a critical role in development and tissue homeostasis. Caspases, a family of cysteine-dependent aspartatedirected proteases, play a critical role in the initiation and execution of apoptosis. In this study, cytotoxicity and apoptogenic effect of 2-phenyl 4-carboxamide derivatives were evaluated in SKNMC (human neuroblastoma), MCF-7 (human breast adenocarcinoma) and HT-29 (human colon cancer) cell lines. Cell viability was determined by MTT assay. Also, activation of caspase-3 was evaluated by spectrophotometry. The overall cytotoxicity profiles of derivatives demonstrated that the HT-29 cell line has more sensitivity respect to other cell lines. Moreover, our observations indicated that 3-F and 2-F derivatives and 4-Cl derivative increased caspase-3 activation in three carcinoma cell line compared to control. Collectively, these findings suggest that these derivatives are able to induce apoptosis in cancer cell lines.
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Copyright
© 2012, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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