Hepatoprotective Activity of Royal Jelly on Mercuric Chloride–induced Damage Model in Rats

Cyrus Jalili; Shiva Roshankhah; Amir Jalali; Mohammad reza Salahshoor

doi:10.4103/jrptps.JRPTPS_27_19

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https://doi.org/10.4103/jrptps.JRPTPS_27_19

Hepatoprotective Activity of Royal Jelly on Mercuric Chloride–induced Damage Model in Rats

Author(s):

Cyrus Jalili

¹,

Shiva Roshankhah

²,

Amir Jalali³,

Mohammad reza Salahshoor

^2,*

1Department of Anatomical Sciences, Medical Biology Research Center, Kermanshah, Iran

2Department of Anatomical Sciences, Faculty of Medicine, Kermanshah, Iran

3Department of Nursing, Faculty of Nursing and Midwifery, Kermanshah University of Medical Sciences, Kermanshah, Iran

Journal of Reports in Pharmaceutical Sciences:Vol. 8, issue 2; 181-7

Published online:Dec 31, 2019

Article type:Research Article

How to Cite:Cyrus JaliliShiva RoshankhahAmir JalaliMohammad reza SalahshoorHepatoprotective Activity of Royal Jelly on Mercuric Chloride–induced Damage Model in Rats.J Rep Pharm Sci.8(2):e147377.https://doi.org/10.4103/jrptps.JRPTPS_27_19.

Abstract

Background: Mercuric chloride (MC) is the chemical composition of mercury and chlorine with many side effects such as oxidative stress referring to mercury toxicity. Royal jelly (RJ) as a honey bee secretion has antioxidant activities. This study was designed to evaluate the effects of RJ against the parameters of hepatic damage in male rats induced by MC toxicity.
Materials and Methods: In this study, 48 male rats were randomly assigned into six groups: sham (saline) and MC control (50 mg/kg) groups; RJ groups (200 mg/kg RJ for 1 day and 200 mg/kg RJ for 7 days, orally) and MC + RJ groups (200 mg/kg RJ orally + 50 mg/kg MC intraperitoneally for 1 day, and 200 mg/kg RJ orally and 50 mg/kg MC intraperitoneally for 7 days). Griess technique was used for the determination of serum nitric oxide (NO) level. Aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) concentrations were determined for liver functional disturbances value. In addition, thiobarbituric acid reactive species, antioxidant capacity, the diameter of hepatocytes, and the central hepatic vein (CHV) were investigated.
Results: MC administration significantly increased the liver malondialdehyde (MDA) and NO levels, the mean diameter of CHV and hepatocyte, hepatic enzymes, and decreased tissue Ferric reducing antioxidant power (FRAP) level compared to the sham group (P < 0.01). The RJ and RJ + MC in all treatments significantly reduced the mean diameter of hepatocyte and CHV, hepatic enzymes, renal MDA and NO levels, and increased tissue FRAP level compared to the MC control group (P < 0.01). It seems that RJ administration recovers the hepatic injury induced by MC in rats.

Keywords

Honey bees

liver/drug effects

mercuric chloride/toxicity

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Author(s):

Cyrus Jalili:[PubMed][Scholar]
Shiva Roshankhah:[PubMed][Scholar]
Amir Jalali:[PubMed][Scholar]
Mohammad reza Salahshoor:[PubMed][Scholar]