Synthesis of Novel Amide Containing Schiffs Bases of 5-(4- Chloro-Phenyl)-Furan-2-Carboxaldehyde: Their In Vivo Anti- Inflammatory, Antioxidant and Antinociceptive Activities with Ulcerogenic Risk Evaluation

authors:

avatar Saqlain Haider 1 , avatar Mohammad Sarwar Alam 1 , * , avatar Hinna Hamid 1 , avatar Sadiq Umar 2 , avatar Deepak Kumar 3 , avatar Syed Nazreen 1

Department of Chemistry, Faculty of Science, Jamia Hamdard (Hamdard University) New Delhi -110 062, India
Department of Toxicology, Faculty of Science, Jamia Hamdard(Hamdard University), New Delhi -110062, India
Department of Pharmaceutical Chemistry, Sikkim Central University, Sikkim-737136, India
Journal of Reports in Pharmaceutical Sciences: Vol.7, issue 1; 44-63
published online: November 05, 2017
article type: Research Article
received: September 02, 2017
revised: October 14, 2017
accepted: October 27, 2017

how to cite: Haider S, Sarwar Alam M, Hamid H, Umar S, Kumar D, et al. Synthesis of Novel Amide Containing Schiffs Bases of 5-(4- Chloro-Phenyl)-Furan-2-Carboxaldehyde: Their In Vivo Anti- Inflammatory, Antioxidant and Antinociceptive Activities with Ulcerogenic Risk Evaluation. J Rep Pharm Sci. 2018;7(1):e147598. 

Abstract

A library of eighteen amide containing Schiffs bases has been synthesized and screened for their anti-inflammatory, antioxidant and antinociceptive activities. The compound 2 (COX-1 IC50 = 63.23 μM; COX-2 IC50 = 1.80 μM; SI = 35.12) exhibited potent selective COX-2 inhibition as compared to indomethacin (COX-1 IC50 = 3.60 μM; COX-2 IC50 = 7.50 μM; SI = 0.48). The compounds 2 and 7 reduced the COX-2 level to 7.5 ±0.35 nmole/min/ml and 6.8 ± 0.32nmole/min/ml respectively. The compounds 6 exhibited reduced the TNF-α level to 3.36 ± 0.18pg/ml. The compounds 2, 6, 7, 13 and 17 did not induce any gastric ulceration in comparison to the standard drug indomethacin.