Protective Effect of Trogopogon Graminifolius Hydroalcoholic Extract against Acute Ethanol Induced Liver Damages in Rat

Maryam Feyzmahdavi; Mozafar Khazaei; Babak Gholamin; Zahra Abbasabadi

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Protective Effect of Trogopogon Graminifolius Hydroalcoholic Extract against Acute Ethanol Induced Liver Damages in Rat

Author(s):

Maryam Feyzmahdavi¹,

Mozafar Khazaei

^1,*,

Babak Gholamin²,

Zahra Abbasabadi¹

1Fertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran

2Department of Pharmacology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Journal of Reports in Pharmaceutical Sciences:Vol. 6, issue 2; 161-166

Published online:Aug 09, 2017

Article type:Research Article

Received:May 12, 2017

Accepted:Jul 24, 2017

How to Cite:Maryam FeyzmahdaviMozafar KhazaeiBabak GholaminZahra AbbasabadiProtective Effect of Trogopogon Graminifolius Hydroalcoholic Extract against Acute Ethanol Induced Liver Damages in Rat.J Rep Pharm Sci.6(2):e147614.

Abstract

Ethanol induces different side effects on tissues and organs and it is associated with biochemical, physiological, and pathological alterations in the liver. Tragopogon graminifolius (TG) is traditionally used for the treatment of gastrointestinal disorders. The aim of present study was to investigate TG effect against ethanol induced liver enzyme (ALT, AST and ALP) and nitric oxide (NO) secretion in male rat. In this experimental study, 30 male Wistar rats (210 ±10 g) have been randomly divided into the experimental, ethanol and control groups (6/group). The experimental groups were received one of TG hydroalcoholic extract (50, 100 and 150 mg/kg) for 15 days orally. One ml of distilled water was given to ethanol and control group daily. At the day of 15th, ethanol (5 g/kg) was given to all groups orally except control group. After one hour, cardiac blood sample was collected and serum levels of ALT, ALP, AST and NO concentration were measured. Data were analyzed by one way-ANOVA test. Ethanol increased ATL, AST, AP and NO in the serum of male rat. Pretreatment with TG extract prevent increasing the serum level of ALT (p=0.001), ALP (p=0.004) and NO (p=0.000) significantly during ethanol consumption. Moreover, serum AST decreased in experimental groups (p>0.05). TG extract has protective effect on ethanol-induced liver toxicity in rats and also verified claims of traditional medicine about hepatoprotective function of TG.

Keywords

Trogopogon Graminifolius

Ethanol

liver

Rat

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