Cardiac up-regulation of apolipoprotein D in a rat model of hypo- and hyperthyroidism

authors:

avatar Marziyeh Salami , avatar Hamid Reza Sameni ORCID , avatar Abbas Pakdel , * , avatar Abbas Ali Vafaei , avatar Roghayeh Pakdel ORCID

Koomesh: Vol.23, issue 3; 409-414
published online: August 01, 2021
article type: Research Article
received: July 02, 2020
accepted: November 01, 2020

how to cite: Salami M, Sameni H R, Pakdel A, Vafaei A A, Pakdel R. Cardiac up-regulation of apolipoprotein D in a rat model of hypo- and hyperthyroidism. koomesh. 2021;23(3):e149961. 

Abstract

Introduction: Cardiac tissue is one of the organs affected by thyroid hormones imbalances. Apolipoprotein D is a multifunctional glycoprotein that is expressed in various tissues including heart tissue. The aim of this study was to evaluate the effect of both hypothyroidism and hyperthyroidism on the level of apolipoprotein D protein in the heart tissue. Materials and Methods: In order to induce hypothyroidism and hyperthyroidism in white mice, propylthiouracil (PTU, 100 ppm) and levothyroxine (L-T4, 8 ppm) dissolved in water  and were used for 6 weeks, respectively. ELISA method was used to measure the total T3 hormone in rat serum. After confirming the model, the mice were anesthetized and the heart tissue was removed and the ventricle and apex of the heart were used for histological examination. Immunohistochemistry was used to evaluate the expression level of apolipoprotein D. Results: We showed for the first time that the expression of apolipoprotein D in the hearts of hypothyroid (P

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