Abstract
Introduction:
Inherited retinal diseases are the most common causes of blindness in developed countries, including Retinitis Pigmentosa disease as an inherited retinal degeneration, leading to the blindness of patients by loss of photoreceptor activity.
Materials and Methods:
In this review, we introduce the basic knowledge about optogenetics and also summarize the application of optogenetics as a non-invasive tool in the treatment of retinal diseases.
Results:
There are several therapies that offer optogenetics as a non-invasive technique with light-sensitive proteins such as opsins, the ability to genetically modify these diseases using light.
Conclusion:
Due to the transparency of the eye, optical stimulation of nerve cells and optical receptors in the eye and changing their function through depolarization of the target cell membrane can be a more effective method than other treatments. Optogenetics is a novel method in medical science that can be effective in treating many retinal diseases by using gene therapy and optical methods.
Keywords
Optogenetics Retinitis Pigmentosa Animal opsin Microbial opsin inherited retinal degeneration
Copyright
© 2024, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.