Effects of eight weeks resistance training on brain derived neurotrophic factor in female patients with multiple sclerosis

authors:

avatar Mehrzad Moghadasi , * , avatar mohammad amin edalat manesh , avatar aida moeini , avatar mohadeseh namatollahzadeh

Koomesh: Vol.17, issue 1; 152-159
published online: December 21, 2015
article type: Research Article
received: July 01, 2013
accepted: April 02, 2015

how to cite: Moghadasi M, edalat manesh M A, moeini A, namatollahzadeh M. Effects of eight weeks resistance training on brain derived neurotrophic factor in female patients with multiple sclerosis. koomesh. 2015;17(1):e150776. 

Abstract

 Introduction: Neurotrophins like (brain-derived neurotrophic factor, BDNF) is thought to play an important role in neuronal repair. Recent experimental evidence noted that BDNF decrease in patients with multiple sclerosis (MS) and exercise may increases the level of this protein. The purpose of this study was to evaluate the effect of eight weeks resistance training on BDNF in female patients with MS. Materials and Methods: Twenty seven female MS patients with 32.4 ± 5.5 years of old, and expanded disability status scale (EDSS) 1-5, participated in this study. The subjects were randomly assigned to control group (n=13) or training group (n=14). Subjects in training group performed selected upper and lower extremities resistance training with weight-training equipment and rubber bands 3 days a week for 8 weeks. Results: The results showed that body weight, body mass index, body fat mass and EDSS were decreased 2.5, 3.4, 5.1 and 27.7 percentage respectively after eight weeks in training group compared to control group (P