Efficacy of glucosamine compounds phonophoresis in knee osteoarthritis

Rozita Hedayati; Atefeh Aminianfar; Malihe Darbani; Mansoore-sadat Dadbakhsh; Fatemeh Ehsani

Koomesh

Journal of Semnan University of Medical Sciences

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Efficacy of glucosamine compounds phonophoresis in knee osteoarthritis

Author(s):

Rozita Hedayati

,

Atefeh Aminianfar

^,*,

Malihe Darbani,

Mansoore-sadat Dadbakhsh,

Fatemeh Ehsani

Koomesh:Vol. 18, issue 2; 276-285

Published online:Dec 28, 2016

Article type:Research Article

Received:Sep 06, 2016

Accepted:Nov 07, 2016

How to Cite:Rozita HedayatiAtefeh AminianfarMalihe DarbaniMansoore-sadat DadbakhshFatemeh EhsaniEfficacy of glucosamine compounds phonophoresis in knee osteoarthritis.koomesh.18(2):e151136.

Abstract

Introduction: Knee osteoarthritis (OA) is the most common joint disease characterized by deterioration of articular cartilage. Pharmacological treatments mainly emphasize on the regeneration of articular cartilage. Glucosamine sulfate is used as a cartilage protective substance with controversial results. This study was designed to investigate the efficacy of glucosamine phonophoresis on the knee osteoarthritis. Materials and Methods: This clinical trial was performed on 41 female patients aged 45-75 years (21 unilateral and 20 bilateral cases). Patients randomly assigned into one of three groups. Group 1: This group received standard treatment with ultrasound (US)/off (n=15) Group 2: This group received standard treatment with US/on (n=12) (US was in continuous mode at frequency of 1 MHz and 0.3 watt/cm2 intensity, 5 min duration increasing gradually during the treatment sessions) and Group 3: This group received glucosamine phonophoresis (with equal ratio of %50 gel and glucosamine, and US/on as the same parameters). All treatment sessions were done daily on the dominant knee and for 30 sessions. Standard treatment included daily and on the dominant knee infrared, transcutaneous ekectrical stimulation and exercise. Pain, active knee flexion range of motion, swelling of knee joint, morning stiffness and quality of life (QOL) of all participants were measured before and after the intervention. Results: The data showed significant improvement in OA criteria (more decreased pain swelling and morning stiffness, improvement in knee flexion and QOL index) in the intervention group than other placebo groups (P

Keywords

التهاب استخوان و مفصل

گلوکزآمین

مفصل زانو

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