Efficacy of glucosamine compounds phonophoresis in knee osteoarthritis

authors:

avatar Rozita Hedayati ORCID , avatar Atefeh Aminianfar ORCID , * , avatar Malihe Darbani , avatar Mansoore-sadat Dadbakhsh , avatar Fatemeh Ehsani ORCID

Koomesh: Vol.18, issue 2; 276-285
published online: December 28, 2016
article type: Research Article
received: September 06, 2016
accepted: November 07, 2016

how to cite: Hedayati R, Aminianfar A, Darbani M, Dadbakhsh M, Ehsani F. Efficacy of glucosamine compounds phonophoresis in knee osteoarthritis. koomesh. 2016;18(2):e151136. 

Abstract

Introduction: Knee osteoarthritis (OA) is the most common joint disease characterized by deterioration of articular cartilage. Pharmacological treatments mainly emphasize on the regeneration of articular cartilage. Glucosamine sulfate is used as a cartilage protective substance with controversial results. This study was designed to investigate the efficacy of glucosamine phonophoresis on the knee osteoarthritis. Materials and Methods: This clinical trial was performed on 41 female patients aged 45-75 years (21 unilateral and 20 bilateral cases). Patients randomly assigned into one of three groups.  Group 1: This group received standard treatment with ultrasound (US)/off (n=15) Group 2: This group received standard treatment with US/on (n=12) (US was in continuous mode at frequency of 1 MHz and 0.3 watt/cm2 intensity, 5 min duration increasing gradually during the treatment sessions) and  Group 3: This group  received glucosamine phonophoresis (with equal ratio of %50 gel and  glucosamine, and US/on as the same parameters). All treatment sessions were done daily on the dominant knee and for 30 sessions. Standard treatment included daily and on the dominant knee infrared, transcutaneous ekectrical stimulation and exercise. Pain, active knee flexion range of motion, swelling of knee joint, morning stiffness and quality of life (QOL) of all participants were measured before and after the intervention. Results: The data showed significant improvement in OA criteria (more decreased pain swelling and morning stiffness, improvement in knee flexion and QOL index) in the intervention group  than other placebo groups (P

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