Prevalence of toxoplasma gondii and the level of IL8 in patients with Celiac disease

authors:

avatar Mohammad Rostami-Nejad , avatar Seyed Hossein Hejazi , * , avatar Mehran Bahadoran , avatar Nader Pestehchian , avatar Mohammad Amin Pourhosseingholi , avatar Ahmad Hosseini Safa , avatar Amir Sadeghi , avatar Hossein Nobakht , avatar Reza Tajabadi Farahani , avatar Mohammad Reza Zali

Koomesh: Vol.18, issue 1; 79-85
published online: September 28, 2016
article type: Research Article
received: November 02, 2015
accepted: April 03, 2016

how to cite: Rostami-Nejad M, Hejazi S H, Bahadoran M, Pestehchian N, Pourhosseingholi M A, et al. Prevalence of toxoplasma gondii and the level of IL8 in patients with Celiac disease. koomesh. 2016;18(1):e151148. 

Abstract

Introduction: Toxoplasma gondii infection is usually detected by using immunoglobulin IgG and IgM antibodies in different populations. This parasite is implicated in the pathogenesis of many autoimmune diseases such as celiac disease (CD). In the present study the prevalence of Toxoplasmosis and the level of IL8 in patients with Celiac disease were evaluated. Materials and Methods: In this case-control study in 2013, 150 patients with CD diagnosis were selected by using questionnaire and the presence of antibodies specific for Toxoplasma gondii (IgG, IgM) was detected by ELISA. On the other hand the level of IL8 was detected using available commercial kit. Results: patients (n=59, 39.9%) were positive for anti-toxoplasma IgG. On the other hand, only 2 of them were positive for IgM antibodies, which did not show statistical correlation to the disease (1.4%, P = 0.65). The mean level of IL8 was 176.38 (SD=191.79) in 150 CD patients, which did not show a statistical significant correlation between the mean level of IL8 and celiac disease (P=0.001). Conclusion: Like other studies showing that intestinal infection can help to develop celiac disease in susceptible individuals, our results also revealed that Toxoplasma gondii infection can increase the risk of developing celiac disease.

References

  • 1.

    Rostami K, Malekzadeh R, Shahbazkhani B, Akbari MR, Catassi C. Coeliac disease in Middle Eastern countries: a challenge for the evolutionary history of this complex disorder? Dig Liver Dis 2004; 36: 694-697.

  • 2.

    Ludvigsson JF, Askling J, Ekbom A, Montgomery SM. Diagnosis underlying appendectomy and coeliac disease risk. Dig Liver Dis 2006; 38: 823-828.

  • 3.

    Dubey, JP. "History of the discovery of the life cycle of Toxoplasma gondii". Int J Parasitol 2009; 39: 877-882.

  • 4.

    Rostami Nejad M, Mahbobipour H, Fazeli Z, Mashayekhi R, Mirsatari D, Nazemalhosseini Mojarad E, et al. Celiac disease in Iranian dyspeptic patients. Koomesh 2011; 12: 209-214. (Persian).

  • 5.

    Rostami Nejad M, Rostami K, Cheraghipour K, Nazemalhosseini Mojarad E, Volta U, Al Dulaimi D, Zali MR. Celiac disease increases the risk of toxoplasma gondii infection in a large cohort of Iranian pregnant women. Am J Gastroenterol 2011; 106: 548-549.

  • 6.

    Plot L, Amital H, Barzilai O, Ram M, Nicola B, Shoenfeld Y. Infections may have a protective role in the etiopathogenesis of celiac disease. Ann N Y Acad Sci 2009; 1173: 670-674.

  • 7.

    Ruggeri CAT, LaMasa S, Rudi M, Squadrito G, Di Pasquale G, Maimone S, et al. Celiac disease and non-organ-specific autoantibodies in patients with chronic hepatitis C virus infection. Dig Dis Sci 2008; 53: 2151-2155.

  • 8.

    Mashayekhi K, Rostami-Nejad M, Azimzadeh P, Amani D, Kazemian S, Derakhshani S, et al. Setup of SYBR green real-time PCR method to detect the HLA-DQ alleles in patients with celiac disease. Koomesh 2015; 16: 527-535.

  • 9.

    Carlsson AK, Lindberg BA, Bredberg AC, Hyty H, Ivarsson SA. Enterovirus infection during pregnancy is not a risk factor for celiac disease in the offspring. J Pediatr Gastroenterol Nutr 2002; 35: 649-652.

  • 10.

    Carroccio A, Cavataio F, Montalto G, Paparo F, Troncone R, Iacono G. Treatment of giardiasis reverses active coeliac disease to latent coeliac disease. Eur J Gastroenterol Hepatol 2001; 13: 1101-1105.

  • 11.

    Verdu EF, Mauro M, Bourgeois J, Armstrong D. Clinical onset of celiac disease after an episode of Campylobacter jejuni enteritis. Can J Gastroenterol 2007; 21: 453-455.

  • 12.

    Prandota JT. gondii Infection Acquired during Pregnancy and/or after Birth may be Responsible for Development of both Type 1 and 2 Diabetes Mellitus. J Diabetes Metab 2013; 4: 2.

  • 13.

    Severance EG, Kannan G, Gressitt KL, Xiao J, Alaedini A, Pletnikov MV, Yolken RH. Anti- gluten immune response following Toxoplasma gondii infection in mice. PLoS One 2012; 7: e50991.

  • 14.

    Rostom A, Murray JA, Kagnoff MF. American Gastroenterological Association (AGA) Institute technical review on the diagnosis and management of celiac disease. Gastroenterology 2006; 131: 1981-2002.

  • 15.

    Rashtak S, Murray JA. Tailored testing for celiac disease. Ann Intern Med 2007; 147: 339-341.

  • 16.

    Craig D, Robins G, Howdle PD. Advances in celiac disease. Curr Opin Gastroenterol 2007; 23: 142-148.

  • 17.

    Kasper LH. Toxoplasma infection. Harrison's principles of internal medicine. 15th Edition. McGraw-Hill 2001; pp: 1222-1226.##.