Effects of methadone maintenance therapy onsexual function indrugdependent men

authors:

avatar Afshin Ahmadvand , avatar Zahra Sepehrmanesh , * , avatar Rezvan Saei , avatar SeyedGholamAbass Moosavi

Koomesh: Vol.17, issue 4; 796-802
article type: issue_documents_importer
received: May 06, 2014
accepted: February 01, 2016

how to cite: Ahmadvand A, Sepehrmanesh Z, Saei R, Moosavi S. Effects of methadone maintenance therapy onsexual function indrugdependent men. koomesh. 2024;17(4):e151170. 

Abstract

Introduction: Sexual dysfunction is a common problem among substance abusers. This study investigates the effect of methadone maintenance therapy on men sexual function. Materials and Methods: In this semi- experimental study, 30 men who received methadone were selected by convenient sampling method and monitored for 3 months. Glombock Rust Inventory state and demographic characteristics questionnaires were used for evaluation of patients. The assessment of patient’s sexual function was performed before and after methadone therapy. Results: The mean of global sexual function scores before methadone therapy was 6.1±2/2 and after 6.9±2/3 (P=0.1). Also the mean of subscales impotence, premature ejaculation, non-sensuality, avoidance and non-communication were not significant before and after methadone therapy. While, the mean of dissatisfaction and infrequency subscales showed significant differences before and after methadone (P=0.03, P=0.0001).In this study the relation between age and duration of substance abuse with sexual function was significant (P=0.0001, P=0.02) but the relation between other demographic variables with sexual dysfunction was not significant. Conclusion: These findings showed that methadone has been increased sexual dysfunction in some parts of sexual function. Therefore, patients should be screened for sexual dysfunction at the onset of opioid replacement treatment and also they should be introduced for suitable treatment for prevention of the severity of disorders and improvement of quality of marital relationship

References

  • 1.

    Dole VP, Nyswander M. Methadone maintenance 4 decades later thousands of lives saved but still controversial. JAMA 2008; 300: 2303-2305.

  • 2.

    Van den Brink W, Haasen C. Evidenced-based treatment of opioid-dependent patients. Can J Psychiatry 2006; 51: 635-646.

  • 3.

    Langendam MW, Van Brussel GH, Coutinho RA, Van Ameijden EJ. The impact of harm-reduction-based methadone treatment on mortality among heroin users. Am J Public Health 2001; 91: 774-780.

  • 4.

    Ward J, Mattick RP, Hall W. The effectiveness of methadone maintenance treatment: an overview. Drug Alcohol Rev 1994; 13: 327-335.

  • 5.

    Bell J, Hall W, Byth K. Changes in criminal activity after entering methadone maintenance. BR J Addict 1992; 87: 251-258.

  • 6.

    He Q, Wang XR, Xia YH, Mandel JS, Chen A, Zhao L, et al. New community-based methadone maintenance treatment programs in Guangdong, China and their impact on patientquality of life. Subst Use Misuse 2011; 46: 7469-7757.

  • 7.

    Strain EC, Bigelow GE, Liebson IA, Stitzer ML. Moderate- vs high-dose methadone in the treatment of opioid dependence: a randomized trial. JAMA 1999; 281: 1000-1005.

  • 8.

    Brown RT, Zueldorff M. Opioid substitution with methadone and burenorphine: sexual dysfunction as a side effect of theray. Aheroin Addict Relat Clin Probl 2007; 9: 35-44.

  • 9.

    Goldsmith DS, Hunt DE, Lipton DS, Strug DL. Methadone folklore: beliefs about side effects and their impact on treatment. Human Org 1984; 43: 330-340.

  • 10.

    Brown R, Balousek S, Mundt M, Fleming M. Methadone maintenanceand male sexual dysfunction. J Addict Dis 2005; 24: 91-106.

  • 11.

    Deglon JJ, Martin JL, Imer RL. Methadone patients sexual dysfunctions: clinical and treatment issues. Heroin Add Rel Clin Probl 2004; 6: 17-26.

  • 12.

    Wang P, Zhu JH, Yan J, Wang CH, Xu HM. Study of conditions of sexual function in male patients by MMT. Chin J Hum Sexual 2007; 16: 19-36.

  • 13.

    Bai X, Liu N, Jia W, Zhang X. Study on sexual function of male MMT patients. Chin J Drug Abuse Prev Treat 2009; 15: 158-160.

  • 14.

    Shabsigh R. Hypogonaism and erectile dysfunction: The role for testoserone therapy. Int J Impot Res 2003; 15: S9-s13.

  • 15.

    Tatari F, Farniya V, Faghiyeh Nasiri R, Najafi F. The effects of Trazodone on erectile functionin patients on methadone maintenance treatment 2010, Available from: URL: www.Kums.ac.ir/article-fa-78.html.

  • 16.

    Quaglio G, Lugoboni F, Pattaro C, Melara B, Mezzelani P. Erectile dysfunction in male heroin users, receiving methadone and buprenorphine maintenance treatment. Drug Alcohol Dependence 2008; 94: 12-18.

  • 17.

    Hanbury R, Cohen M, Stimmel B. Adequacy of sexual performance in men maintained on methadone. Am J Drug Alcohol Abuse 1977; 4: 13-20.

  • 18.

    Spring WD Jr, Willenbring ML, Maddux TL. Sexual dysfunctionand psychological distress in methadone maintenance. Int J Addict 1992; 27: 1325-1334.

  • 19.

    Bliesener N, Albrecht S, Schwager A, Weckbecker K, LichtermannD, Klingmller D. Plasma testosterone and sexual function in men receiving buprenorphine maintenance for opioid dependence. J Clin Endocrinol Metabo 2004; 90: 203-206.

  • 20.

    Sargolzaii MR. Survey of sexual dysfunction after opiate withdrawal. First congress of dependency. Iran: Zahedan 2000: 17-19.

  • 21.

    Chekuri V, Gerber D, Brodie A, Krishnadas R. Premature ejaculation and other sexual dysfunctions in opiate dependent men receiving methadone substitution treatment. Add Behav 2012; 37: 124-126.

  • 22.

    Yao Z, Peng W, Zilong MA, Zaifeng XU, Yi L. Sexual function of 612 male addicts treated by methadone. J Cent South Univ (Med Sci) 2011; 36: 739-743.

  • 23.

    Besharat MA, Hoseinzadeh Bazargani R. A comparative study of fertile and infertile womens mental health and sexual problems. Andeesheh va Raftar 2006; 12: 146-153. (Persian).

  • 24.

    Roshanpajuh M, Khodaei MR, Tafie E, Rezaei O, Nazeri Astaneh A, Baghestani AR, et al. The effect of methadone on sexual function in male dependent to opiates. Speci Issue Addic Studi 2012; 12: 65-71. (Persian).

  • 25.

    Halinan R, Byrne A, Agho K, McMahon C, Tynan P, Attia J. Erectile dysfunction in men receiving methadone and buprenorphine maintenance treatment. J Sexual Med 2008; 5: 684-692.

  • 26.

    Babakhanian M, Eghlima M, Raheb Gh. Alternative survey of men sexual dysfunctions with opioid substance misuse under methadone maintenance therapy. J Res Addict 2011; 5: 85-98. (Persian).

  • 27.

    Teusch L, Scherbaum N, Bohme H, Bender S, Eschmann-Mehl G, Gastpar M. Different pattern sof sexualdys functions associated with psychiatric disorder sand psychopharmacological treatment: results of an investigation by semi-structured interview of schizophrenic and neurotic patients and methadone-substituted opiate addicts. Pharmacopsychiatry 1995; 28: 84-92.##.