Role of brain-derived neurotrophic factor receptor on the anxiety levels in rats following the acute administration of morphine

authors:

avatar Masoumeh Khalil-Khalili , avatar Shahrbanoo Ghodrati-Jaldbakhan , avatar A. li Rashidy-Pour , avatar Ahmad Reza Bandegi , avatar Behpoor Yousefi , avatar Hossein Miladi-Gorgi , *

Koomesh: Vol.17, issue 3; 718-724
published online: September 28, 2016
article type: Research Article
received: February 02, 2016
accepted: March 08, 2016

how to cite: Khalil-Khalili M, Ghodrati-Jaldbakhan S, Rashidy-Pour A L, Bandegi A R, Yousefi B, et al. Role of brain-derived neurotrophic factor receptor on the anxiety levels in rats following the acute administration of morphine. koomesh. 2016;17(3):e151221. 

Abstract

Introduction: The aim of this study was to examine anxiolytic effects of acute morphine and the role of BDNF receptor on that effect in adult rats. Materials and Methods: In this experiment, 48 adult male Wistar rats (200–250 g) were randomly assigned to six groups. Rats were given an acute dose of morphine (10 mg/kg, s.c.) and after 2hours, single dose of ANA12 (BDNF receptor antagonist) was injected (0.25, 0.5 mg/kg, i.p). After 4h, rats were examined in the EPM to assess the level of their anxiety. Control rats similarly received saline. Results: An increase was observed in the percentage of time spent in the open arm in the saline rats receiving ANA12 injection. However, the number of open or closed arm entries was less and more, respectively, in the morphine rats receiving ANA12 injection. Conclusion: Our findings showed a modulatory role of BDNF/TrkB receptor in the anxiolytic effects of acute morphine.

References

  • 1.

    Bartoletti M, Gaiardi M, Gubellini C, Bacchi A, Babbini M. Morphine attenuation of a conditioned emotional response in post-dependent rats. Eur J Pharmacol 1990; 185: 163-167.

  • 2.

    Motta V, Brando ML. Aversive and antiaversive effects of morphine in the dorsal periaqueductal gray of rats submitted to the elevated plus-maze test. Pharmacol Biochem Behav 1993; 44: 119-125.

  • 3.

    Zarrindast MR, Rostami P, Zarei M, Roohbakhsh A. Intracerebroventricular effects of histaminergic agents on morphineinduced anxiolysis in the elevated plusmaze in rats. Basic Clin Pharmacol Toxicol 2005; 97: 276-281.

  • 4.

    Privette T, Terrian D. Kappa opioid agonists produce anxiolytic-like behavior on the elevated plus-maze. Psychopharmacology 1995; 118: 444-450.

  • 5.

    Zarrindast M-R, Babapoor-Farrokhran S, Babapoor-Farrokhran S, Rezayof A. Involvement of opioidergic system of the ventral hippocampus, the nucleus accumbens or the central amygdala in anxiety-related behavior. Life Sci 2008; 82: 1175-1181.

  • 6.

    Miladi-Gorji H, Rashidy-Pour A, Fathollahi Y. Anxiety profile in morphine-dependent and withdrawn rats: effect of voluntary exercise. Physiol Behav 2012; 105: 195-202.

  • 7.

    Koo JW, Mazei-Robison MS, Chaudhury D, Juarez B, LaPlant Q, Ferguson D, et al. BDNF is a negative modulator of morphine action. Science 2012; 338: 124-128.

  • 8.

    Sarhan M, Pawlowski SA, Barthas F, Yalcin I, Kaufling J, Dardente H, et al. BDNF parabrachio-amygdaloid pathway in morphine-induced analgesia. Int J Neuropsychopharmacol 2013; 16: 1649-1660.

  • 9.

    Quesseveur G, David D, Gaillard M, Pla P, Wu M, Nguyen H, et al. BDNF overexpression in mouse hippocampal astrocytes promotes local neurogenesis and elicits anxiolytic-like activities. Translat Psychiatry 2013; 3: e253.

  • 10.

    Bergami M, Rimondini R, Santi S, Blum R, Gtz M, Canossa M. Deletion of TrkB in adult progenitors alters newborn neuron integration into hippocampal circuits and increases anxiety-like behavior. Proc Natl Acad Sci U S A. 2008; 105: 15570-15575.

  • 11.

    Cazorla M, Jouvenceau A, Rose C, Guilloux J-P, Pilon C, Dranovsky A, Prmont J. Cyclotraxin-B, the first highly potent and selective TrkB inhibitor, has anxiolytic properties in mice. PLoS One 2010; 5: e9777.

  • 12.

    Cazorla M, Prmont J, Mann A, Girard N, Kellendonk C, Rognan D. Identification of a lowmolecular weight TrkB antagonist with anxiolytic and antidepressant activity in mice. J Clin Invest 2011; 121: 1846-1857.

  • 13.

    Kase H, Iwahashi K, Nakanishi S, Matsuda Y, Yamada K, Takahashi M, et al. K-252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases. Biochem Biophys Res Commun 1987; 142: 436-440.

  • 14.

    Boulle F, Kenis G, Cazorla M, Hamon M, Steinbusch HW, Lanfumey L, van den Hove DL. TrkB inhibition as a therapeutic target for CNS-related disorders. Prog Neurobiol 2012; 98: 197-206.

  • 15.

    Shirayama Y, Chen AC-H, Nakagawa S, Russell DS, Duman RS. Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression. J Neurosci 2002; 22: 3251-3261.

  • 16.

    Siuciak JA, Lewis DR, Wiegand SJ, Lindsay RM. Antidepressant-like effect of brain-derived neurotrophic factor (BDNF). Pharmacol Biochem Behav 1997; 56: 131-137.

  • 17.

    Eisch AJ, Bolanos CA, de Wit J, Simonak RD, Pudiak CM, Barrot M, et al. Brain-derived neurotrophic factor in the ventral midbrainnucleus accumbens pathway: a role in depression. Biol psychiatry 2003; 54: 994-1005.

  • 18.

    Lu H, Cheng P-l, Lim BK, Khoshnevisrad N, Poo M-m. Elevated BDNF after cocaine withdrawal facilitates LTP in medial prefrontal cortex by suppressing GABA inhibition. Neuron 2010; 67: 821-833.

  • 19.

    Berton O, McClung CA, DiLeone RJ, Krishnan V, Renthal W, Russo SJ, et al. Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress. Science 2006; 311: 864-868.

  • 20.

    Torregrossa MM, Isgor C, Folk JE, Rice KC, Watson SJ, Woods JH. The delta-opioid receptor agonist (+) BW373U86 regulates BDNF mRNA expression in rats. Neuropsychopharmacology 2004; 29: 649-659.