Antinociceptive effects of aqeous extract Launaea acanthodes gum in mice

authors:

avatar Hossein Nazari , avatar Shayan Bidokhty , avatar Abolfazl Mohammadi , avatar Maryam Jafari , avatar Abbasali Taherian , *

Koomesh: Vol.19, issue 1; 154-163
published online: March 28, 2017
article type: Research Article
received: May 02, 2016
accepted: October 02, 2016

how to cite: Nazari H, Bidokhty S, Mohammadi A, Jafari M, Taherian A. Antinociceptive effects of aqeous extract Launaea acanthodes gum in mice. koomesh. 2017;19(1):e151332. 

Abstract

Introduction: Previous studies indicated that Launaea acanthodes (LA) can be effective against epilepsy, nervous disorder, local and articular pain and convulsion disorders. The aim of this study was to assessment the antinoceceptive effects of  LA on peripheral and visceral pain in mice by using hot plate (HP), tail flick (TF), formalin (FT) and writhing (WR) tests. Materials and Methods: In this study 160 young adult male albino mice (25-30 g) were used (n = 8 in each group). Aqueous extract of LA gum (50, 100, and 200 mg/Kg IP) and saline (SAL) were injected 30 min before the pain evaluation tests. Acute and chronic pain was assessed by HP, TF and FT models and visceral pain was assessed by writhing test. Results: Results indicated that LA has analgesic effects (P< 0.05) in comparison with the control and saline groups  and higher dose of LA was more effective (P< 0.001). Conclusion: The above findings showed that LA have modulatory effects on acute, chronic and visceral pain

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