Effects of forced exercise on neuropathic pain induced by chronic constriction injury of sciatic nerve in male rat

authors:

avatar Hossein Ali Safakhah , avatar Atiye Bazargani , avatar Ali Ghanbari , *

Koomesh: Vol.17, issue 2; 411-418
published online: March 28, 2016
article type: Research Article
received: July 03, 2015
accepted: October 02, 2015

how to cite: Safakhah H A, Bazargani A, Ghanbari A. Effects of forced exercise on neuropathic pain induced by chronic constriction injury of sciatic nerve in male rat. koomesh. 2016;17(2):e151359. 

Abstract

Introduction: Central and peripheral nerve injuries may lead to chronic neuropathic pain in addition to immobility in many injured persons. Exercise as a non-medical procedure has beneficial effects on the well being of individuals in normal and diseased state. Therefore, in the current study we aimed to measure the alleviating effect of physical exercise on neuropathic pain. Materials and Methods: Male wistar rats weighting 200±20 gram were divided into 5 groups: Intact, sham, neuropathic, exercise before neuropathy, and exercise after neuropathy. After anesthesia, rats underwent chronic constriction injury (CCI) procedure to induce neuropathic injury on the left sciatic nerve. After surgery animals were transferred to individual cages and covered with a towel to prevent hypothermia until regaining consciousness. Mechanical allodynia and thermal hyperalgesia were detected using von Frey Filament and Plantar test, respectively. Results: Mechanical and thermal withdrawal response thresholds were reduced significantly (P