Journal of Semnan University of Medical Sciences
Effects of forced exercise on neuropathic pain induced by chronic constriction injury of sciatic nerve in male rat
Authors
Abstract
Introduction: Central and peripheral nerve injuries may lead to chronic neuropathic pain in addition to immobility in many injured persons. Exercise as a non-medical procedure has beneficial effects on the well being of individuals in normal and diseased state. Therefore, in the current study we aimed to measure the alleviating effect of physical exercise on neuropathic pain. Materials and Methods: Male wistar rats weighting 200±20 gram were divided into 5 groups: Intact, sham, neuropathic, exercise before neuropathy, and exercise after neuropathy. After anesthesia, rats underwent chronic constriction injury (CCI) procedure to induce neuropathic injury on the left sciatic nerve. After surgery animals were transferred to individual cages and covered with a towel to prevent hypothermia until regaining consciousness. Mechanical allodynia and thermal hyperalgesia were detected using von Frey Filament and Plantar test, respectively. Results: Mechanical and thermal withdrawal response thresholds were reduced significantly (P
Highlights
Copyright
© 2016, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
Similar Articles
Effects of co-administration of chronic curcumin and forced exercise on behavioral pain responses in the neuropathic pain model of chronic constriction injury in rats
Baratzadeh H, Safakhah HA, Rashidy-Pour AL, Talebi A, Jarrahi M. Effects of co-administration of chronic curcumin and forced exercise on behavioral pain responses in the neuropathic pain model of chronic constriction injury in rats. koomesh. 2022;24(3):e152746. doi:
The effects of co-administration of curcumin and forced exercise on electrophysiological responses in the neuropathic pain model of chronic constriction injury of peripheral nerves in rats
Baratzadeh H, Safakhah HA, Rashidy Pour A, Jarrahi M. The effects of co-administration of curcumin and forced exercise on electrophysiological responses in the neuropathic pain model of chronic constriction injury of peripheral nerves in rats. koomesh. 2023;25(2):e154152. doi:
Effects of combined chronic progesterone administration and forced exercise on behavioral pain responses in the neuropathic pain model of chronic constriction injury in rats
Khazani F, Jarrahi M, Rashidy Pour A, Vafaeenejad A, Safakhah HA. Effects of combined chronic progesterone administration and forced exercise on behavioral pain responses in the neuropathic pain model of chronic constriction injury in rats. koomesh. 2021;23(2):e153266. doi:
Combined effect of chronic progesterone administration with compulsive exercise on prevention of TNF-α production and abnormal electrophysiological responses of sciatic nerve in Chronic Constriction injury pain model in rat
Safakhah HA, Jarrahi M, rashidypour A, Babndegi A, Khazani F. Combined effect of chronic progesterone administration with compulsive exercise on prevention of TNF-α production and abnormal electrophysiological responses of sciatic nerve in Chronic Constriction injury pain model in rat. koomesh. 2021;23(1):e154062. doi:
Role of saphenous nerve in the behavioral responses of neuropathic pain – due to chronic constriction injury in rats
Safakhah HA, Monahji H. Role of saphenous nerve in the behavioral responses of neuropathic pain – due to chronic constriction injury in rats. koomesh. 2004;6(1):e152033. doi:
More by these authors
- Scopus by DOI: 0
Last Update: 3 weeks ago
- Scopus by Title: 8
Last Update: 3 weeks ago
- Scopus by Title (Ref): 8
Last Update: 3 weeks ago
- CrossRef: 0
Last Update: 4 days ago